Sökning: "acenocoumarol"

Hittade 2 avhandlingar innehållade ordet acenocoumarol.

  1. 1. The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9

    Författare :Mike Ufer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; cytochrome P450; genetic polymorphism; genotyping; CYP2C9; phenprocoumon; warfarin; acenocoumarol; oral anticoagulants;

    Sammanfattning : Oral anticoagulants are widely used for the prevention of thromboembolic disorders. Warfarin (WA) is most commonly used world-wide, while phenprocoumon (PPC) is the first-line anticoagulant in some European countries including Germany. Each anticoagulant exists in two different enantiomeric forms and is administered orally as a racemate. LÄS MER

  3. 2. Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology

    Författare :Umit Yasar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CYP2C9 polymorphism; phenotyping; genotyping; diclofenac; losartan;

    Sammanfattning : Cytochrome P450 2C9 (CYP2C9) is one of the most important drug metabolizing enzymes in human liver. It catalyses the metabolism of a wide range of different drugs such as S-warfarin, acenocoumarol, losartan, irbesartan, phenytoin, sulphamethoxazole, tolbutamide, glipizide and numerous non-steroidal antiinflammatory drugs. LÄS MER