Sökning: "absorptive capacity"
Visar resultat 21 - 25 av 40 avhandlingar innehållade orden absorptive capacity.
21. Particle Transcytosis Across the Human Intestinal Epithelium : Model Development and Target Identification for Improved Drug Delivery
Sammanfattning : The use of nano- and micro-particulate carriers as delivery systems for oral vaccines has been under investigation for several decades. Surprisingly little is known of their uptake in the human intestine, despite the fact that substantial improvement is required to achieve adequate immune responses in man after oral administration. LÄS MER
22. European knowledge transfer reflected by research collaboration and patent citations indicators
Sammanfattning : Knowledge transfer consists of activities that aim to capture and transmit knowledge, skills and competence from those who generate them to those who will transform them into socio-economic outcomes. In the context of the March 2000 Lisbon strategy and its aim to make the European Union the “world's most dynamic and competitive knowledge economy”, knowledge transfer is considered to play an important role in helping to overcome obstacles such as a weak environment to stimulate high quality research and exploit research results. LÄS MER
23. Energy demand management in selected African countries
Sammanfattning : This thesis contains five empirical papers that contribute to the energy demand management literature on Africa. It investigates the following policy issues – business cycle and energy conservation, government fuel subsidies and energy efficiency, economic growth and environmental quality, structural effects in parameters, the transition between energy efficiency and energy inefficiency, forecast of energy demand, shifts in demand behaviour, and the persistence profile of energy demand to shocks – using data from five countries: Algeria, Nigeria, South Africa, Cameroon and Ghana. LÄS MER
24. Development of the gastrointestinal tract in young mammals : Effects of enteral provocation with protease or phytohaemagglutinin in neonatal rats
Sammanfattning : The rat, as an altritial species, is born with an immature gastrointestinal tract and intestinal barrier function, which is highly absorptive to milk-borne bioactive molecules that can pass undigested and reach the general circulation of the suckling newborn. This passage occurs by the neonatal-Fc-receptor (FcRn) binding and trancytosis of immunoglobulin G in the proximal small intestine (SI) and by the highly endocytic vacuolated enterocytes non-selectively in the distal SI. LÄS MER
25. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model
Sammanfattning : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. LÄS MER