Sökning: "a pathway"

Visar resultat 1 - 5 av 2633 avhandlingar innehållade orden a pathway.

  1. 1. A structural study of ribokinase from Escherichia coli

    Författare :Jill A. Sigrell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; ATP-binding; conformational changes; kinase; ribose; X-ray crystallography; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Ribokinase phosphorylates the abundant sugar ribose, using ATP in the presence of magnesium. The phosphorylation is the first reaction in ribose metabolism and the product, ribose-5-phosphate, can enter the pentose phosphate pathway and glycolysis. It can also be used in the synthesis of histidine and purines. LÄS MER

  3. 2. Uncovering a Novel Pathway for Autoinflammation : With a Little Help from a Wrinkled Friend

    Författare :Mia Olsson; Kerstin Lindblad-Toh; Gerli Pielberg; Göran Andersson; Leif Andersson; Rikard Holmdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoinflammation; hyaluronic acid; amyloidosis; canine model; genetic association; Molekylär genetik; Molecular Genetics;

    Sammanfattning : A major challenge in medical genetics is to identify the mutations underlying heritable diseases. Dogs are excellent genetic models in the search for causative mutations, as they constitute a large library of naturally occurring heritable diseases many of which are analogous to those suffered by man. LÄS MER

  4. 3. Stolen genes, a shortcut to success : Evolution of metabolic and detoxification capacities in Diplomonads

    Författare :Alejandro Jimenez-Gonzalez; Jan Andersson; Thomas A. Richards; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Diplomonads; Parasitism; Evolutionary Genomics; Metabolism; Lateral Gene Transfer;

    Sammanfattning : Parasites do not represent a single evolutionary lineage meaning that they have evolved several times. The changes that parasites have undergone to adapt to such a lifestyle are not entirely understood. LÄS MER

  5. 4. A molecular biological study of Alzheimer's disease : investigation of amyloid precursor protein, amyloid precursor-like protein 2 and presenilin-1

    Författare :Janet A Johnston; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The devastating symptoms of Alzheimer's disease result from a progressive regional neurodegenerative process, the cause of which is unknown. Current research suggests that several different mechanisms may be involved, perhaps acting at different points in a common pathological pathway. LÄS MER

  7. 5. Sharecom internationalisation : Exploring business models, business ecosystems, and pathways to international expansion

    Författare :Heidi Coral Thornton; Richard A. Owusu; Emilia Rovira Nordman; Linnéuniversitetet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; sharing economy; sharecom; digital platform; business model; business ecosystem; entry strategy; internationalisation pathway; internationalisation; Business administration; Företagsekonomi;

    Sammanfattning : An ever-changing business landscape, rapid developments in digital technologies, and shifts in societal attitudes have paved the way for the sharing economy phenomenon. Over the past decade, sharing economy companies (sharecoms) have emerged in droves, shaking up industry structures globally with their innovative business models and novel valuecreating processes, which rely on the externalised resources. LÄS MER