Sökning: "Yersinia"
Visar resultat 16 - 20 av 61 avhandlingar innehållade ordet Yersinia.
16. Molecular mechanism of plasmid copy number control in Yersinia
Sammanfattning : The ability of pathogenic bacteria to cause disease depends on various virulence mechanisms. The three pathogenic species of Yersinia use a type III secretion system (T3SS) to translocate effector proteins into host cells and disrupt the immune system. This T3SS is encoded on a 70kb, low-copy, virulence plasmid. LÄS MER
17. Host-pathogen interactions during Campylobacter and Yersinia infections
Sammanfattning : The innate immune system is known for protecting the host against invading pathogens, for instance enteropathogens infecting the gastrointestinal tract. The production of e.g. antimicrobial peptides, cytokines, and chemokines by innate immune cells and intestinal epithelial cells contribute to bacterial clearance. LÄS MER
18. Coordinating type III secretion system biogenesis in Yersinia pseudotuberculosis
Sammanfattning : Various Gram-negative bacteria utilize type III secretion system (T3SS) to deliver effectors into eukaryotic host cells and establish mutualistic or pathogenic interactions. An example is the Ysc-Yop T3SS of pathogenic Yersinia species. LÄS MER
19. Type III secretion- the various functions of the translocon operon in bacterial pathogenesis
Sammanfattning : In order to establish colonisation of a human host, pathogenic Yersinia use a type III protein secretion system to directly intoxicate host immune cells. Activation of this system requires target cell contact and is a highly regulated process. LÄS MER
20. A strategy to identify novel antimicrobial compounds : a bioinformatics and HTS approach
Sammanfattning : Bacterial infections are again becoming difficult to treat because the microbes are growing increasingly resistant to the antibiotics in use today. The need for novel antimicrobial compounds is urgent and to achieve this new targets are crucial. In this thesis we present a strategy for identification of such targets via a bioinformatics approach. LÄS MER