Sökning: "YKL-40"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet YKL-40.

  1. 1. Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease

    Författare :Joakim Hertze; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; mild cognitive impairment; white matter lesions; brain reserve; blood-brain barrier; angiogenesis; neuroinflammation; neurogranin; YKL-40; VEGF; IGF; ICAM-1; VCAM-1;

    Sammanfattning : Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. LÄS MER

  3. 2. Viral wheeze and risk factors for childhood asthma : an evaluation of clinical, immunological and genetic factors

    Författare :Katarina Stenberg Hammar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It’s not fully understood why some children wheeze with viral infections, and why some develop severe asthma. In this study we compared two study groups; children presenting with acute wheeze (AW) before the age of four and age-matched healthy controls (HC), and we investigated factors that might contribute to increased vulnerability for airway infections and risk of later asthma development. LÄS MER

  4. 3. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    Författare :Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; Uppsala universitet; []
    Nyckelord :Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Sammanfattning : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. LÄS MER

  5. 4. Investigating problematic severe asthma in children : a translational approach

    Författare :Jon R Konradsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Children with problematic severe asthma (PA) have persistent symptoms and/or severe exacerbations despite treatment with high doses of currently available asthma medications. The term PA includes children who are difficult to treat due to unidentified exacerbating factors (e.g. LÄS MER

  7. 5. Cerebrospinal fluid studies of bipolar disorder

    Författare :Anniella Isgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar disorder; Cerebrospinal fluid; Biomarkers; Pathophysiology; Proteomics; Neuroimmunology; Cytokines;

    Sammanfattning : The pathophysiology of bipolar disorder remains to be elucidated. One approach to studying brain processes is analysis of cerebrospinal fluid (CSF). LÄS MER