Sökning: "Y2-receptor"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet Y2-receptor.

  1. 1. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor

    Författare :Esbjörn Melin; Epilepsicentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; neuropeptide Y NPY ; Y2 receptor; GDNF; Encapsulated cell biodelivery; seizure; In-vivo;

    Sammanfattning : Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. LÄS MER

  3. 2. Studies of the Neuropeptide Y Receptor Y2 in Human and Zebrafish

    Författare :Helena Fällmar; Dan Larhammar; Ingrid Lundell; Nina Mohell; Raquel E. Rodríguez Rodríguez; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Y2-receptor; NPY; PYY; G-protein-coupled receptor; mutagenesis; receptor binding; zebrafish; evolution; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Sammanfattning : The G-protein coupled receptors (GPCRs) comprise the largest family of receptors in humans and other vertebrates. They are embedded in the cell membrane and are activated by many different signaling molecules. Activation modulates cellular signal transduction pathways and influences many physiological processes. LÄS MER

  4. 3. Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin

    Författare :Litsa Nikitidou; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; Neuropeptide Y; Y2 receptor; Y5 receptor; Galanin; Encapsulated cell biodelivery; Vascular endothelial growth factor; Flk-1; Hippocampus;

    Sammanfattning : Epilepsy is a severe chronic neurological disorder, affecting about 1% of the population. The disease is manifested by spontaneous recurrent seizures, caused by hypersynchronized neuronal activity due to imbalance in the brain between the inhibition and excitation. LÄS MER

  5. 4. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    Författare :Andreas Toft Sörensen; Experimentell Epilepsi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTP; synaptic plasticity; synaptic transmission; electrophysiology; Y5 receptor; Y2 receptor; neuropeptide Y NPY ; hippocampus; gene therapy; epilepsy; memory; activity-dependent release; volume transmission;

    Sammanfattning : Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. LÄS MER

  7. 5. Characterization of NPY receptors Y1, Y2 and Y5 expression and function in vivo

    Författare :Hessameh Hassani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NPY; NPY receptors; knockout mice; behavior; food intake; pain; peripheral nerve injury; inflammation; inflammatory bowel disease.;

    Sammanfattning : The general aim of these studies was to further elucidate the role of NPY receptors in the regulation of the food intake and energy homeostasis, nociception, and inflammation. We have utilized both normal and genetically modified mice, and a number of different techniques to study these mechanisms. LÄS MER