Sökning: "Y-chromosome"

Visar resultat 16 - 20 av 32 avhandlingar innehållade ordet Y-chromosome.

  1. 16. Gonad development and male gametogenesis

    Författare :Christina Österlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Testicular and ovarian organogenesis involve a pathway of developmental genes which are differentially regulated in males and females. In mammals, sex determination is controlled by a dominant gene, SRY, located on the Y chromosome. LÄS MER

  3. 17. Genetic Sex Differences in Early Human Neuronal Development : An Investigation in Embryo Tissue and Embryonic Stem Cells

    Författare :Philipp Pottmeier; Elena Jazin; Armin Raznahan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex chromosome; gametolog; x y homolog; male; female; sex differences; sex bias; embryonic stem cells; neurodevelopment; neuronal differentiation; neural stem cells; genetics; neurodevelopmental disorders; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi; Neuroscience; Neurovetenskap; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Sex differences in the human body affect many different organs and tissues, some of them have an effect on the human brain and its development. In the developing nervous system, sex differences can bias the number or functionality of neurons, glial cells or synapses. As a result, neural networks might develop with a sex-specific bias. LÄS MER

  4. 18. Detection of donor cells in recipient tissues after stem cell transplantation using FISH and immunophenotyping

    Författare :Monika Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Haematopoietic stem cell transplantation (HSCT) is curative therapy for many malignant and non-malignant diseases. Effective conditioning regimen is an important component of HSCT in order to achieve a successful engraftment and to pursue a curative treatment. Conditioning regimens consist of chemotherapy with or without total body irradiation. LÄS MER

  5. 19. Studies of human endogenous retroviruses and of the TGF-beta signaling pathway

    Författare :Christian Kjellman; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high-density filter array; gliom; TGF-beta; XA34; Human endogenous retrovirus; HERV-F; transplantation; serologi; Immunologi; serology; Immunology;

    Sammanfattning : The human genome, in common with all mammalian genomes, carries a high load of inheritable retroviral sequences. We have identified and characterized a novel family of these endogenous retroviruses and have named this family HERV-F as based on the primer binding sites of three members. LÄS MER

  7. 20. Population genetic history and patterns of admixture : Examples from northeastern and southern Africa

    Författare :Nina Hollfelder; Mattias Jakobsson; Michele Ramsay; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; population structure; genetic admixture; genomic variation; Africa; population genomics; lactase persistence; sex-biased admixture; human evolutionary genetics; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi;

    Sammanfattning : The origin of humans lies in Africa, as has been shown by archaeology, paleontology and genetics. Here, we can find the largest genetic diversity and the deepest split among human populations. African genetic diversity has been shaped by a long and complex history. LÄS MER