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1. 1. Interplay between Transcription and Homologous Recombination in the Presence of DNA Damage

   Författare :Ivaylo Stoimenov; Thomas Helleday; Niklas Schultz; Natalia Issaeva; Thierry Nouspikel; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homologous recombination; transcription; DRB; UVC; 6-thioguanine; mammalian cells; BRCA1; BRCA2; PARP inhibitors; XP-V; Molecular biology; Molekylärbiologi; molekylärgenetik; Molecular Genetics;

   Sammanfattning : The biochemical processes of DNA repair, replication and recombination compete for the same substrate, the DNA molecule. This competition is natural, as each process requires the same template. In order to resolve possible conflicts between these processes, when they take place on a particular stretch of DNA, certain crosstalk is expected. LÄS MER