Sökning: "X-chromosome inactivation"

Visar resultat 6 - 10 av 16 avhandlingar innehållade orden X-chromosome inactivation.

  1. 6. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation

    Författare :Marie-Line Faucillion; Jan Larsson; Jean-Yves Roignant; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; dosage compensation; buffering; RNA stability; RNA decay; RNA half-life; RNA-seq; genome-wide; sex chromosomes; evolution; roX1; roX2; POF; MSL; molekylärbiologi; Molecular Biology;

    Sammanfattning : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). LÄS MER

  3. 7. Principles of transcriptional bursting in mammalian cells

    Författare :Anton Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In mammalian cells, transcription occurs in discrete bursts leading to fluctuations in transcripts from expressed genes. Although this behavior was first reported not long after the discovery of messenger RNA (mRNA), the methods to measure transcriptional bursting have been limited in throughput and scalability. LÄS MER

  4. 8. Laminins in stemness and germ cell development in human

    Författare :Magdalena Kurek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Stem cell niches regulate the fine balance between self-renewal and differentiation of various stem cells. Although crucial hallmarks of stem cell niches, such as the mechanical signalling, neural inputs communicating distant cues, the proximity to blood vessels and the structural support by the surrounding basement membrane (BM), have been evaluated in different niches, little much attention has been directed to the specific composition of the BM. LÄS MER

  5. 9. Exploring mammalian preimplantation development and pluripotency

    Författare :John Paul Schell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our current understanding of how stem cells arise and transition during embryonic development has been limited by analysis tools that have lacked single-cell, whole-genome resolution. This thesis emphasizes the use of novel techniques and cutting-edge technology to better evaluate the biological underpinning of stem cell dynamics in both mouse and human. LÄS MER

  7. 10. Bleeding tendency and health-related quality of life in carriers of haemophilia

    Författare :Anna Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carriers of haemophilia; Bleeding; SF-36; Thrombin generation; Genotype;

    Sammanfattning : Haemophilia A and B are X-linked disorders caused by impaired synthesis of coagulation factors VIII and IX, respectively. Women who carry the haemophilia trait have about 50 % of normal factor levels. LÄS MER