Sökning: "Wnt"

Visar resultat 16 - 20 av 149 avhandlingar innehållade ordet Wnt.

  1. 16. Early development of the olfactory placode and early rostrocaudal patterning of the caudal neural tube

    Författare :Esther Maier; Lena Gunhaga; Fernando Giraldez; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; olfactory placode; caudal neural tube; Wnt; FGF; RA; BMP; Notch; patterning; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The development of the nervous system is a complex process. Cell divisions, cell differentiation and signalling interactions must be tightly regulated. To comprehend the mature nervous system, we have to understand its assembly during development. LÄS MER

  3. 17. Exploring the tissue-specific nature of the Wnt cell signaling system : The complex world of cell communication and the search for the Achilles heel of cancer

    Författare :Simon Söderholm; Claudio Cantù; Mikael Benson; Stefan Hoppler; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling; β-catenin; Development; Cancer; Stem cells; Omics; Bioinformatics;

    Sammanfattning : The Wnt signaling pathway is a biological mechanism for cell-cell communication found across all species of the animal kingdom. This pathway plays a major role in virtually all stages of embryonic development, and it governs central aspects of stem cell biology, regeneration, and tissue homeostasis. LÄS MER

  4. 18. NOTUM and RSPO3 in Bone - WNT signaling modulators regulating the skeleton

    Författare :Karin H. Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NOTUM; RSPO3; WNT signaling; Bone;

    Sammanfattning : Osteoporosis is a skeletal disease affecting millions of people worldwide, often leading to fragility fractures and a decreased quality of life. There is an unmet medical need for new anabolic, bone building, treatments. LÄS MER

  5. 19. Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing

    Författare :Anna Thorfve; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling pathway; Osteoarthritis; Bone regeneration; Lithium;

    Sammanfattning : The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to numerous diseases, whereas controlled modulation of the Wnt signaling activity is an attractive target e.g. LÄS MER

  7. 20. Wnt-5a Signalling in Human Mammary Cells: Implications for the Development of Breast Cancer

    Författare :Marzieh Jönsson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; signalling; breast cancer; Wnt-5a; mammary epithelial cells; cancer; onkologi; Cytologi; cancerology;

    Sammanfattning : The Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. LÄS MER