Sökning: "Wegener´s granulomatosis"

Hittade 5 avhandlingar innehållade orden Wegener´s granulomatosis.

  1. 1. Clinical and Epidemiological Studies of Wegener´s Granulomatosis

    Författare :Ann Knight; Roger Hällgren; Johan Askling; Anders Ekbom; Lennart Jacobsson; Uppsala universitet; []
    Nyckelord :Medicine; Wegener´s granulomatosis; incidence; time-trends; ANCA; familial aggregation; cancer risks; bladder cancer; cyclophosphamide; Medicin;

    Sammanfattning : Wegener´s granulomatosis (WG) is an unusual, serious, systemic vasculitis with specific clinical findings. The studies in this thesis aim at broadening our understanding of the aetiology and outcome of WG.Patients with WG were identified in the In-patient Register 1975-2001. LÄS MER

  2. 2. Autoimmunity in glomerulonephritis; serological diagnosis and clinical outcome with special reference to Wegener´s granulomatosis and microscopic polyangiitis

    Författare :Kerstin Westman; Njurmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wegener´s granulomatosis; vasculitis; thyroid peroxidase antibodies; proteinase 3; myeloperoxidase; antineutrophil cytoplasmic antibodies; ANCA; thyroiditis; autoantibodies; glomerulonephritis; microscopic polyangiitis; Urology; nephrology; Urologi; nefrologi;

    Sammanfattning : Autoantibodies of different specificites have been described in association with glomerulonephritis and therefore the aim of this thesis was to improve our knowledge of the different manifestations of autoimmune phenomena which are involved in the glomerulonephritides. Special reference is made to Wegener´s granulomatosis (WG) and microscopic polyangiitis (MP) which are frequently associated with the prevalence of anti-neutrophil cytoplasmic antibodies (ANCA). LÄS MER

  3. 3. Mechanisms of endothelial cell dysfunction in Wegener´s granulomatosis

    Författare :Carolina Holmén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Wegener´s granulomatosis; vasculitis; anti-endothelial cell antibody; circulating endothelial cell; vascular adhesion protein 1; MHC class-I related chain A;

    Sammanfattning : Vasculitides are a heterogeneous group of disorders that share a common feature of blood vessel inflammation. A major cell type of the blood vessel affected is the endothelial cell (EC). LÄS MER

  4. 4. Endothelial cells : Dysfunction and repair mechanisms

    Författare :Elzafir Elsheikh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Endothelial cells; endothelial progenitor cells; Wegener s granulomatosis; atherosclerosis; myocardial infarction; menstruation cycle; stromal cell-derived factor-1;

    Sammanfattning : Endothelial cells (ECs) are crucial component of the normal vascular wall, providing an interface between the bloodstream and surrounding tissue of the blood vessel wall. Endothelial progenitors cells (EPCs) circulate in the blood and migrate to regions of the circulatory system with injured endothelium and ischemic tissues. LÄS MER

  5. 5. Immunological studies on anca-associated vasculitis with special reference to T cell activation

    Författare :Marta Christensson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : This thesis focuses on the role of T cells in ANCA-associated vasculitis. We initially investigated activation markers on T cells in patients with Wegener s granulomatosis (WG), microscopic polyangiitis (MPA) and renal limited disease (RLD) and found increased expression indicating continuous activation despite clinical remission. LÄS MER