Sökning: "WAY-100635"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet WAY-100635.

  1. 1. Photoinitiated Radical Carbonylation Using [11C]Carbon Monoxide : 11C-Labelling of Aliphatic Carboxylic Acids, Esters, and Amides

    Författare :Oleksiy Itsenko; Bengt Långström; Tor Kihlberg; Chryssostomos Chatgilialoglu; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; 11C-labelling; radicals; carbonylation; carbon monoxide; solvent effects; sensitizers; sulfoxides; WAY-100635; PET; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : One-step photoinitiated free radical carbonylation was employed for the rapid (5–7 min) labelling of aliphatic carboxylic acids, esters, and amides with a short-lived positron emitter 11C (t½ = 20.3 min) at the carbonyl position. The labelled compounds were synthesized from alkyl iodides (0.05–0. LÄS MER

  3. 2. Experimental studies on novel pharmacological strategies in the treatment of schizophrenia

    Författare :Amani Eltayb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; L-dopa; topiramate; 5-HT2C; citalopram; WAY 100635; CAR; catalepsy;

    Sammanfattning : The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state which is believed to generate negative and cognitive symptoms. Positive symptoms are improved by typical antipsychotic drug (APD) treatment. LÄS MER

  4. 3. PET studies of the serotonin transporter in the human brain

    Författare :Johan Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

    Sammanfattning : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. LÄS MER

  5. 4. Development of positron emission tomography radioligands for the dopaminergic and serotonergic neurotransmission systems

    Författare :Camilla Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; Radioligand; Dopamine transporter; Serotonin transporter; 5-HT1A receptor; 5-HT2A receptor;

    Sammanfattning : The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to several neuropsychiatric disorders. The main objectives were to develop new suitable radioligands for positron emission tomography (PET) examinations of the dopamine transporter (DAT) as well as the serotonin 5-HT1A and 5-HT2A-receptors. LÄS MER

  7. 5. Development of radioligands for the serotonergic neurotransmission system for use in positron emission tomography

    Författare :Johan Sandell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; Radioligand; Brain; 5-HT1A receptor; serotonin transporter;

    Sammanfattning : The serotonergic system is implicated in several neuropsychiatric disorders, such as depression, anxiety and schizophrenia. Several hypotheses on the pathophysiology of these disorders are based on the pharmacology of serotonergic drugs. Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depression and anxiety. LÄS MER