Sökning: "Voltage-gated Ca2 Channels"

Visar resultat 21 - 25 av 33 avhandlingar innehållade orden Voltage-gated Ca2 Channels.

1. 21. Intracellular signaling of phosphorylated insitol compounds : a study in pancreatic beta-cells and hippocampal neurons

   Författare :Jia Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :InsP6; L-type Ca 2 channel; hippocampal neuron; Ins 1; 4; 5 P3; Ca2 ; cyt-MIPP; pancreatic beta-cell; PtdIns 3; 4; 5 P3; Ptdlns 3; 5 P2.;

   Sammanfattning : The family of phosphorylated inositol compounds consists of soluble cytosolic inositol phosphates and insoluble inositol phospholipids, localized in cellular membranes and the nuclear matrix. Although inositol phospholipids only account for 5-10% of total plasma membrane lipids, these compounds and their inositol phosphate derivatives play an important role in a broad range of cellular processes including intracellular Ca 2+ signalling, ion channel regulation, vesicle trafficking, both exo- and endocytosis, cell growth and apoptosis. LÄS MER

3. 22. Regulation of eukaryotic cell physiology using organic bioelectronics

   Författare :Karl Svennersten; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The field of organic bioelectronics deals with the implementation of conducting polymer science in biology and medicine. The purpose of this thesis was to develop organic bioelectronic devices for the regulation of eukaryotic cell physiology. LÄS MER

4. 23. Stimulation of insulin secretion independently from changes in cytosolic free Ca²+-concentration : studies with imidazolines and inositol polyphosphates

   Författare :Alexander Efanov; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :insulin secretion; pancreatic ß-cell; imidazolines; inositol polyphosphates;

   Sammanfattning : Insulin secretion from the islets of Langerhans is regulated by changes in glucose concentration. Glucose stimulates secretion by two mechanisms. First, it increases cytosolic free Ca2+ concentration ([Ca2+]i) by inhibition of ATP-dependent K+-channels (KATP) and induction of membrane depolarization. LÄS MER

5. 24. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

   Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. LÄS MER

7. 25. Serum proteins in type 1 diabetes

   Författare :Nancy Dekki Wenna; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : We have previously shown that there are patients with type 1 diabetes T1D whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i), resulting in �-cell apoptosis. In this study the frequency of sera, that induces this effect, was found to be around 35% in T1D patients, and 25% in first degree relatives (FDR) of T1D patients. LÄS MER