Sökning: "Vladimir basic"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Vladimir basic.

1. 1. Molecular mechanisms mediating development of pulmonary cachexia in COPD

   Författare :Vladimir Basic; Jorge Ruas; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; COPD; cachexia; atrophy; cigarette smoke; myogenesis; angiogenesis; Biomedicin; Biomedicine; Biokemi; Biochemistry;

   Sammanfattning : Cigarette smoking (CS) represents the main causative agent underlying development and progress of COPD. Recently, involvement of CS in the pathogenesis of COPDassociated muscle abnormalities is becoming increasingly evident. Nevertheless, involved triggers and underlying mechanisms remain largely unknown. LÄS MER

3. 2. Dynamics of Coinfection : Complexity and Implications

   Författare :Samia Ghersheen; Vladimir Kozlov; Uno Wennergren; Vladimir Tkachev; Åke Brännström; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Living beings are always on risk from multiple infectious agents in individual or in groups. Though multiple pathogens' interactions have widely been studied in epidemiology. Despite being well known, the co-existence of these pathogens and their coinfection remained a mystery to be uncovered. LÄS MER

4. 3. Preclinical Development of Imaging Agents for HER2 Expression in Prostate Cancer Using Radiolabeled Affibody Molecules

   Författare :Jennie Malmberg; Anna Orlova; Vladimir Tolmachev; Marika Nestor; Eric O. Aboagye; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical Science; Farmaceutisk vetenskap; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : This thesis is focused on pre-clinical evaluation of in vivo detection of HER2-expression in prostate cancer (PCa) patients and on the possibility of using targeted molecular imaging to personalize treatment of disseminated PCa. The work is divided into three distinct parts: (1) the establishment of a preclinical model for further studies, (2) imaging of HER2 in a murine model of PCa and (3) exploration of new treatment regimes against PCa. LÄS MER

5. 4. Prostate cancer theranostics using GRPR antagonist RM26

   Författare :Bogdan Mitran; Anna Orlova; Vladimir Tolmachev; Ulrika Rosenström; Tony Lahoutte; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastrin-releasing peptide receptor GRPR ; Bombesin; Prostate-specific membrane antigen PSMA ; Antagonist; Radionuclide molecular imaging; Theranostics; Peptide receptor radionuclide therapy PRRT .;

   Sammanfattning : The malignant transformation of cells is often associated with an alteration of their molecular phenotype, resulting in overexpression of several cell surface proteins. Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are examples of such pro-teins that are expressed at a high density in prostate cancer. LÄS MER

7. 5. Affibody-Based Molecular Imaging and Targeted Therapy of HER3-Expressing Cancer

   Författare :Sara Sophie Rinne; Anna Orlova; Vladimir Tolmachev; Mohamed Altai; Anzhelika Vorobyeva; Melpomeni Fani; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular Imaging; PET; SPECT; Cancer; Affibody; HER3; Targeted Therapy;

   Sammanfattning : The human epidermal growth factor receptor type 3 (HER3) is overexpressed in different types of cancer and is a known contributor to disease progression and resistance to cancer therapy. This thesis is based on five original articles, which aimed to improve the diagnostic and therapeutic potential of affibody-based agents for management of HER3-expressing cancers. LÄS MER