Sökning: "Viral glycoproteins"
Visar resultat 1 - 5 av 42 avhandlingar innehållade orden Viral glycoproteins.
1. Viral proteins as serological antigens - Development and clinical applications
Sammanfattning : Serological methods are based on the detection of antibodies and antigens in mainly serum but also in other body fluids such as cerebrospinal fluid (CSF). Conventional whole virus antigens are widely used in viral serological assays. LÄS MER
2. Anti-herpes simplex virus activities of sulfomannan oligosaccharide PI-88 and disulfated cyclitols
Sammanfattning : Herpes simplex virus (HSV) initiates invasion of human cells by binding to the cell surface heparan sulfate (HS) glycosaminoglycan chains. This step is mediated by the viral envelope glycoproteins gC and/or gB. LÄS MER
3. Interaction of herpes simplex virus with cell surface glycosaminoglycans as a target for antiviral intervention
Sammanfattning : Herpes simplex virus (HSV) infections in humans are predominantly manifested as oral cold sores or genital ulcers. As HSV infects cells by interaction with cell surface heparan sulfate (HS) and/or chondroitin sulfate (CS), the aim of the research work presented in this thesis was to explore the possibility of antiviral intervention with compounds that mimic HS or CS. LÄS MER
4. Hepatitis C virus. Aspects on natural history, antibody response, and viral quantification
Sammanfattning : Hepatitis C virus (HCV) is the major cause of parenterally transmitted non-A, non-B hepatitis, and is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite the screening of blood products nosocomial spread of HCV continues to occur. LÄS MER
5. Interaction-mediating sequences within class I viral fusion glycoproteins : their roles in viral infection and in applications
Sammanfattning : Class I viral fusion glycoproteins facilitate fusion of the viral envelope with cell membranes and entry of the virus into the cell, through extensive short sequence-specific interactions. Regions mediating these interactions include the N-terminal hydrophobic fusion peptide, a pair of extended 4,3-hydrophobic heptad repeats (HRs), a membrane-active membrane proximal external region (MPER), a hydrophobic transmembrane domain and the cytoplasmic tail region. LÄS MER