Sökning: "Vesicular Glutamate Transporters"

Hittade 5 avhandlingar innehållade orden Vesicular Glutamate Transporters.

1. 1. Early life experiences and alcohol use in youth : An emerging role of the Vesicular Glutamate Transporters

   Författare :Maria Vrettou; Erika Comasco; Ingrid Nylander; Kent W. Nilsson; Åsa Wallén-Mackenzie; Roberto Ciccocioppo; Uppsala universitet; []
   Nyckelord :alcohol; early-life stress; brain; early adulthood; expression; DNA methylation; glutamate; Vesicular Glutamate Transporters;

   Sammanfattning : Initiation of alcohol consumption usually takes place during adolescence, a period characterized by a plethora of physical and emotional changes. Towards early adulthood, hazardous drinking patterns can emerge and potentially lead to the development of Alcohol Use Disorder (AUD). LÄS MER

3. 2. Immunocytochemical studies of excitatory amino acid neurotransmitters and transporters in the spinal cord and nucleus submedius

   Författare :Stefan Persson; Neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurophysiology; neuropsychology; Neurology; VGLUT2; VGLUT1; pain; somatosensory; thalamus; immunogold; glutamate; aspartate; dorsal horn; excitatory amino acids; spinal cord; neurofysiologi; Neurologi;

   Sammanfattning : The amino acid glutamate is today regarded as the main fast excitatory neurotransmitter in the central nervous system and a large body of evidence support that glutamate serves as a neurotransmitter in primary afferent terminals in the spinal cord. Previous evidence also suggests that the closely related amino acid aspartate may serve a similar role in some primary afferent terminals. LÄS MER

4. 3. Signaling Mechanisms in the Neuronal Networks of Pain and Itch

   Författare :Katarzyna Rogoz; Klas Kullander; Malin Lagerström; Stephen McMahon; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse genetics; neuronal network; glutamate; sensory neuron; dorsal root ganglion; pain; itch; Neuroscience; Neurovetenskap; Molekylär genetik; Molecular Genetics;

   Sammanfattning : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. LÄS MER

5. 4. Temporal dynamics of brain plasticity : characterizing brain structural changes during skill acquisition

   Författare :Tomás Mediavilla; Daniel Marcellino; Alexandra Badea; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Motor learning; brain plasticity; structural plasticity; magnetic resonance imaging; voxel-based morphometry; tractography; connectivity; motor cortex; posterior parietal cortex; cerebellum; vesicular glutamate transporter;

   Sammanfattning : Traditionally, structural plasticity in the human brain has been considered to follow a linear or asymptotic increase over the course of training. However, recent studies using structural MRI revealed transient increases in grey matter volume (GMV) with learning. LÄS MER

7. 5. Characterization of Amino Acid Transporters in the Brain : Molecular and Functional Studies of Members within the Solute Carrier Families SLC38 and SLC6

   Författare :Maria Hägglund; Robert Fredriksson; Farrukh Chaudhry; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acid transporter; Solute Carrier; Glutamine; Leucine; SNAT; B0AT; Neuroscience; Neurovetenskap;

   Sammanfattning : Solute carriers (SLCs) comprise the largest group of transporters in humans and there are currently 52 SLC families. They are embedded in cellular membranes and transport numerous molecules; defects in many of the genes encoding SLCs have been connected to pathological conditions, and several SLCs are potential drug targets. LÄS MER