Sökning: "Ventral horn cells"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Ventral horn cells.

  1. 1. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Författare :Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Nyckelord :Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. LÄS MER

  3. 2. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

    Författare :Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Sammanfattning : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. LÄS MER

  4. 3. The use of adipose derived stem cells in spinal cord and peripheral nerve repair

    Författare :Mallappa K Kolar; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; adipose derived stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Sammanfattning : Clinically, injuries affecting the spinal cord or peripheral nerves can leave those affected with severe disability and, at present, there are limited options for treatment. Peripheral nerve injury with a significant gap between the proximal and distal stumps is currently treated with autologous nerve grafting but this is limited by availability of donor nerve and has associated morbidities. LÄS MER

  5. 4. Stem cells in inflammation and regeneration : focusing on animal models of multiple sclerosis and spinal cord injury

    Författare :Sreenivasa Raghavan Sankavaram; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objective of regenerative medicine is to replace or restore injured cells and tissues in the body. Stem cells are identified playing a key role in the regeneration but action of inflammatory mediators in disease is not well understood. LÄS MER

  7. 5. On the cholinergic c-bouton

    Författare :Johan Hellström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; Brainstem; Immunohistochemistry; In situ hybridization; Motoneurons; Muscarinic receptors; Rat; Spinal cord; Ventral horn cells;

    Sammanfattning : The cholinergic C-bouton is a large nerve terminal type exclusively contacting motoneuron cell somata and proximal dendrites. C-boutons are characterized by subsurface cisterns found beneath the postsynaptic membrane, which is an exclusive feature for these nerve terminals. The origin of the C-boutons is unknown. LÄS MER