Sökning: "Ventral Tegmental Area"
Visar resultat 16 - 20 av 50 avhandlingar innehållade orden Ventral Tegmental Area.
16. Glucagon-like peptide-1 and alcohol-mediated behaviors in rodents
Sammanfattning : Alcohol use disorder (AUD) is a serious cause of morbidity and mortality. However, due to the limited efficacy of existing pharmacotherapies, further investigations of potential neurochemical targets are required to define new pharmacological interventions. LÄS MER
17. Appetite-regulating peptides and natural rewards: emphasis on ghrelin and glucagon-like peptide-1
Sammanfattning : Evolutionary conserved natural behaviors, such as foraging and sexual behaviors, are strongly associated with reward processes. Brain areas important for reward processes include, but are not limited to, the nucleus accumbens (NAc) shell, the ventral tegmental area (VTA), the laterodorsal tegmental area (LDTg) and the nucleus of the solitary tract (NTS). LÄS MER
18. On natural and drug-induced reward : genetic, biochemical and behavioral comparisons
Sammanfattning : Work in this thesis compares natural and drug- induced reward at genetic, biochemical and behavioral levels with the objective to obtain information about key mechanisms underlying reward and addiction, and improve the understanding of compulsive elements that characterize addiction. Surveys among committed human runners have described running as addictive. LÄS MER
19. Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects
Sammanfattning : Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was recently approved for treatment of obesity in the US. LÄS MER
20. On retinoid receptors, Nurr1 and related transcription factors in the CNS
Sammanfattning : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). LÄS MER