Sökning: "Ventral Tegmental Area"

Visar resultat 11 - 15 av 50 avhandlingar innehållade orden Ventral Tegmental Area.

  1. 11. Perinatal asphyxia in the rat : a morphological and functional analysis of the dopamine systems and dopamine-mediated behaviours in a novel experimental model

    Författare :Yong Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rat; Perinatal asphyxia; Dopamine; Noradrenaline; Dopamine receptors; Substantia nigra; Ventral tegmental area; Striatum; Accumbens nucleus; Locomotor activity; Attention disorders; bFGF; Fos; pH; pyruvate; lactate; glutamate; aspartate.;

    Sammanfattning : Asphyxia during labour in the human being is one of the important paediatric complications which can lead to various degree of injuries in the central nervous system. No efficient therapy is available at present. LÄS MER

  3. 12. On cholinergic mechanisms involved in ethanol reinforcement. A behavioral and neurochemical study in rodents

    Författare :Anna Larsson; Göteborgs universitet; []
    Nyckelord :Acetylcholine; Dopamine; Ethanol; Locomotor activity; Microdialysis; Nicotine; Nicotinic acetylcholine receptors; Rodents; Reward;

    Sammanfattning : Alcohol (ethanol) and smoking (nicotine) are commonly co-abused in human beings. Drugs of abuse interact with the brain mesolimbic dopamine system, an important part of the brain reward system. These dopaminergic neurons originate in the ventral tegmental area and project to e.g. LÄS MER

  4. 13. Nicotinic mechanisms in ethanol reinforcement. A neurochemical and behavioral study

    Författare :Mia Ericson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Both smoking and alcohol consumption are known to cause severe health problems and there is an extensive co-abuse of tobacco and ethanol. The reinforcing properties of drugs of abuse may involve the brain mesolimbic dopamine system, that originates in the ventral tegmental area (VTA) and projects mainly to the nucleus accumbens. LÄS MER

  5. 14. The gut-brain axis and alcohol-mediated behaviours: the amylin story

    Författare :Aimilia Lydia Kalafateli; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reward; mesolimbic dopamine system; addiction; calcitonin; IAPP;

    Sammanfattning : Alcohol use disorder (AUD) is a complex neuropsychiatric disorder with high rates of mortality and morbidity. The currently available pharmacotherapies show varied efficacy, leading to the investigation of new neurochemical targets for alcohol. LÄS MER

  7. 15. Afferent input to midbrain dopamine neurones and its modulation : an electrophysiological study i vitro

    Författare :Pernilla Grillner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :dopamine neurones; synaptic transmission; NMDA receptors; L-type Ca2 channels; presynaptic inhibition; metabotropic glutamate receptors; muscarine; nicotine;

    Sammanfattning : Dopamine (DA) neurones of the ventral mesencephalon are involved in the control of reward related behaviour, cognitive functions and motor performances, and provide a critical site of action for major categories of neuropsychiatric drugs, such as antipsychotic agents, dependence producing drugs and anti-Parkinson medication. The midbrain DA neurones are mainly located in the substantia nigra pars compacta (SNPC) and the ventral tegmental area (VTA). LÄS MER