Visar resultat 1 - 5 av 303 avhandlingar innehållade ordet Vaccines.
Sammanfattning : Rift Valley Fever virus (RVFV) causes an infection with severe impact on animal and human health. The disease is endemic throughout almost the entire African continent and large regions of the Arabian Peninsula. During epidemics, high mortality is observed in animals, especially among cattle, goats, and sheep. LÄS MER
Sammanfattning : Recombinant techniques provide valuable tools for thedevelopment of modern subunit vaccines. In this thesisdifferent systems for production of recombinant subunitvaccines are presented. The strategies investigated includeprotein immunogens, live bacterial vectors and nucleicacids. LÄS MER
3. Surface expression using the AIDA autotransporter : Towards live vaccines and whole-cell biocatalysis
Sammanfattning : The area of surface expression has gathered a lot of interest from research groups all over the world and much work is performed in the area. Autotransporters have been used for surface expression in Gram-negative bacteria. LÄS MER
Sammanfattning : ALPHAVIRUS VECTORS AS RECOMBINANT VACCINES Peter Berglund Doctoral dissertation from the Microbiology and TumorbiologyCenter Karolinska Institute, Sweden This thesis describes further developments of an expression system based on thealphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structuralproteins, and a 5' ORF coding for the viral replicase. LÄS MER
Sammanfattning : Dendritic cells (DCs) play a central role in the initiation and regulation of innate and adaptive immune responses and have increasingly been applied as vaccines for cancer patients. Ex vivo generation and antigen loading of monocyte-derived DCs allows a controlled maturation, with the aim of imprinting different DC functions that are essential for their subsequent induction of a T cell-mediated anti-tumor response. LÄS MER