Sökning: "VWF"

Visar resultat 1 - 5 av 39 avhandlingar innehållade ordet VWF.

1. 1. The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements

   Författare :Ellen Hanson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ischemic stroke; etiologic subtypes of ischemic stroke; genetics; SNP; hemostasis; prothrombotic; ADAMTS13; VWF; ABO blood group; FSAP; FXI;

   Sammanfattning : Although stroke is a common cause of death and disability in adults, there are few studies on stroke compared to other common diseases. A stroke could be either ischemic or hemorrhagic, but even within these two groups, disease etiology shows heterogeneity. LÄS MER

3. 2. Adipocyte-derived hormones and cardiovascular disease

   Författare :Maria Eriksson; Stefan Söderberg; Tommy Olsson; Lena Jonasson; Umeå universitet; []
   Nyckelord :leptin; adiponectin; fibrinolysis; vWF; myocardial infarction; sex differences; physical activity; risk factors;

   Sammanfattning : Obesity is increasing globally and related to major changes in lifestyle. This increase is associated with an increased risk of cardiovascular disease (CVD). Knowledge about adipose tissue as a metabolic-endocrine organ has increased during the last few decades. LÄS MER

4. 3. ADAMTS13 phenotype in health and disease with special reference to thrombotic thrombocytopenic purpura

   Författare :Minola Manea Hedström; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; tubular cells; podocytes; kidney; plasma; ADAMTS13; thrombotic thrombocytopenic purpura; nephrology; Urologi; nefrologi; Pediatrics; Pediatri;

   Sammanfattning : Von Willebrand factor (VWF) is synthesized and secreted by endothelial cells into the plasma as a series of multimers. VWF induces the formation of platelet plugs at sites of vascular injury and high shear stress. Biological activity is dependent on multimeric size, which is regulated in plasma by the VWF-cleaving protease ADAMTS13. LÄS MER

5. 4. Genetic characterization of families with von Willebrand disease

   Författare :Elsa Lanke; Malmö Klinisk koagulationsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mutation; bleeding; coagulation; von Willebrand disease; genetics;

   Sammanfattning : von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. LÄS MER

7. 5. Studies of the pathogenesis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

   Författare :Diana Karpman; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatri; Pediatrics; tumor necrosis factor; interleukin 6; von Willebrand factor; apoptosis; lipopolysaccharide; shiga-like toxin; Escherichia coli O157:H7; Hemolytic uremic syndrome; thrombotic thrombocytopenic purpura; Urology; nephrology; Urologi; nefrologi;

   Sammanfattning : This study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. LÄS MER