Sökning: "VLDL"

Visar resultat 11 - 15 av 50 avhandlingar innehållade ordet VLDL.

  1. 11. Studies on the assembly and secretion of apolipoprotein B containing lipoproteins

    Författare :Karin Lindberg; Göteborgs universitet; []
    Nyckelord :apolipoprotein B; lipoprotein; lipoprotein biosynthesis; Brefeldin A; microsomal triglyceride transfer protein; liver fatty acid binding protein;

    Sammanfattning : Lipoproteins are water-soluble particles of lipids and proteins, which deliver water-insoluble lipids from intestine or liver to target tissues where the lipids are used as fuel or storage. Lipoproteins consist of a core of hydrophobic lipids surrounded by an amphipatic monolayer of polar lipids and specific proteins, apolipoproteins. LÄS MER

  3. 12. Macrophage Activation and AP-1 in Atherosclerosis

    Författare :Maria Stollenwerk; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Proteins; enzymology; Proteiner; enzymologi; Cardiovascular system; carotid plaque; interleukin-1b; caspase-1.; very low-density lipoprotein; fatty acids; activator protein-1; inflammation; Atherosclerosis; nuclear factor-kB; macrophages; tumor necrosis factor;

    Sammanfattning : High levels of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) have been identified as independent risk factors for coronary heart disease. Hypertriglyceridemia is generally associated with an increased expression of inflammatory makers and inflammation is thought to contribute to atherosclerosis and its complications. LÄS MER

  4. 13. Inflammatory transcription factors in atherosclerosis

    Författare :Wolfgang Dichtl; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : Transcription factors such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) and peroxisome proliferator-activated receptors (PPARs) may play important roles in atherogenesis, by regulating chronic subclinical vascular inflammation. In the first study, we showed that VLDL activates the proinflammatory transcription factor NF-kB in endothelial cells both in vitro and in vivo. LÄS MER

  5. 14. Triglyceride-rich lipoproteins : postprandial metabolism and composition in relation to atherosclerosis

    Författare :Johan Björkegren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :triglyceride-rich lipoproteins; very low density lipoproteins; chylomicrons; lipoprotein remnants; apolipoprotein E and C; cholesterol; atherosclerosis;

    Sammanfattning : A relationship between postprandial lipaemia and coronary heart disease (CHD) was established as early as the 1950s. Since then, most attention has been paid to postprandial triglyceride-rich lipoproteins (TRLs) of intestinal origin, i.e. chylomicrons and chylomicron remnants, whereas TRLs of hepatic origin, i. LÄS MER

  7. 15. PPARs in the regulation of gene expression and lipid metabolism in the liver

    Författare :Ulrika Edvardsson; Göteborgs universitet; []
    Nyckelord :PPARalpha; PPARgamma; PPARgamma2; Wy14; 643; rosiglitazone; liver; hepatocytes; insulin; fatty acids; MTP; ADRP; lipid metabolism; apoB; triglycerides.;

    Sammanfattning : Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, regulating genes involved in carbohydrate, lipid and lipoprotein metabolism. Synthetic PPARalpha agonists used in clinic are the fibrates, and their hypotriglyceridemic effect is believed to be the result of decreased VLDL triglyceride secretion and increased turnover of triglyceride-rich lipoprotein particles in the circulation. LÄS MER