Sökning: "VLDL receptor"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden VLDL receptor.

  1. 1. Growth hormone and PPARa in the regulation of lipoprotein metabolism

    Författare :Daniel Lindén; Göteborgs universitet; []
    Nyckelord :growth hormone; insulin; fatty acids; PPARa; apolipoprotein B; VLDL; mRNA editing;

    Sammanfattning : In humans, apolipoprotein B (apoB)-100 is produced in the liver and apoB-48 is formed in the intestine. In the rat, however, the two forms of apoB are produced in the liver, leading to the formation of VLDL consisting of either apoB-48 or apoB-100. LÄS MER

  3. 2. Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor

    Författare :Jeanna Perman; Göteborgs universitet; []
    Nyckelord :very low density lipoprotein receptor; lipid accumulation;

    Sammanfattning : Lipid accumulation in non adipose tissue is associated with various cases of tissue dysfunction and tissue failure. Reduced availability of oxygen is known to cause intracellular lipid accumulation in cardiomyocytes as well as in hearts. LÄS MER

  4. 3. Assembly and Secretion of Atherogenic Lipoproteins

    Författare :Caroline Beck; Göteborgs universitet; []
    Nyckelord :very low-density lipoprotein; ; apolipoprotein B100; ; B-cell receptor associated; microsomal triglyceride transfer protein; ; secretion; assembly;

    Sammanfattning : The classical dyslipidemia seen in patients with type 2 diabetes is characterized by elevated serum triglycerides (TG), low levels of high-density lipoprotein cholesterol and the appearance of small, dense low-density lipoproteins (LDL). It is now recognized that the different components of diabetic dyslipidemia are not isolated abnormalities but are closely linked to each other metabolically, and are initiated by the hepatic overproduction of large triglyceride-rich very low-density lipoproteins (VLDL1). LÄS MER

  5. 4. Regulation of plasminogen activator inhibitor-1 : role of triglyceride-rich lipoproteins, fatty acids and fibrate compounds

    Författare :Lennart Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :plasminogen activator inhibitor-1; coronary heart disease; endothelial cells; very low density lipoprotein VLDL ; 4G 5G polymorphism; VLDL response element; fibrate compounds; VLDL receptor; stroke;

    Sammanfattning : Impaired fibrinolytic function secondary to elevated plasma plasminogen activator inhibitor-1 (PAI-1) activity is associated with atherothrombotic disease, in particular coronary heart disease. Both environmental and genetic factors contribute to determine plasma PAI-1 levels and PAI-1 production in vivo. LÄS MER

  7. 5. Studies on lipoprotein metabolism and atherogenesis

    Författare :Katharina Slätis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ApoA1; ApoB; ApoE; atherosclerosis; bile acids; cholic acid; cholesterol; cholesterol absorption; CYP7A1; CYP8B1; dexamethasone; GC-1; PAI-1; thyroid hormone receptor; very low density lipoprotein receptor;

    Sammanfattning : Atherosclerosis is the primary cause of cardiovascular events such as angina pectoris and myocardial infarction, which together with stroke are responsible for around 50% of all deaths in the United States and Europe. Usually atherosclerosis develops over several decades and leads to a progressive narrowing of arterial vessels. LÄS MER