Sökning: "VGLUT1-3"

Hittade 4 avhandlingar innehållade ordet VGLUT1-3.

  1. 1. Brain control of energy balance : localization and regulation of proteins involved in the central control of food intake and body weight

    Författare :Maria Collin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AGRP; arcuate nucleus; brainstem; CART; GABA; Glutamate; GPCR; habenular complex; immunohistochemistry; in situ hybridization; hypothalamus; leptin; leptin receptor; LHA; MCH; NPY; Ob-Rb; POMC; serotonin; STAT3; transporter; ventromedial hypothalamic nucleus; VGLUT1-3.;

    Sammanfattning : Obesity has become a worldwide threat to human well-being and is now so common that it is beginning to replace undernutrition and infectious disease as the most significant contributor to ill health. Obesity increases the risk for aquiring serious diseases such as diabetes type 2, hypertension, coronary heart disease and certain forms of cancer. LÄS MER

  3. 2. Early life experiences and alcohol use in youth : An emerging role of the Vesicular Glutamate Transporters

    Författare :Maria Vrettou; Erika Comasco; Ingrid Nylander; Kent W. Nilsson; Åsa Wallén-Mackenzie; Roberto Ciccocioppo; Uppsala universitet; []
    Nyckelord :alcohol; early-life stress; brain; early adulthood; expression; DNA methylation; glutamate; Vesicular Glutamate Transporters;

    Sammanfattning : Initiation of alcohol consumption usually takes place during adolescence, a period characterized by a plethora of physical and emotional changes. Towards early adulthood, hazardous drinking patterns can emerge and potentially lead to the development of Alcohol Use Disorder (AUD). LÄS MER

  4. 3. Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

    Författare :Karin Nordenankar; Åsa Wallén-Mackenzie; Rainer Spanagel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; amphetamine; affective behaviour; cocaine; cognitive behaviour; conditional knockout mouse; dopamine; operant self-administration; reward system; schizophrenia; Neuroscience; Neurovetenskap;

    Sammanfattning : A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. LÄS MER

  5. 4. Signaling Mechanisms in the Neuronal Networks of Pain and Itch

    Författare :Katarzyna Rogoz; Klas Kullander; Malin Lagerström; Stephen McMahon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse genetics; neuronal network; glutamate; sensory neuron; dorsal root ganglion; pain; itch; Neuroscience; Neurovetenskap; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Glutamate is the essential neurotransmitters in pain pathways. The discovery of the vesicular glutamate transporters (VGLUT1-3) has been a fundamental step on the way to describe glutamate-dependent pain pathways. We used the Cre-lox system to construct conditional knockouts with deficient Vglut2 transmission in specific neuronal populations. LÄS MER