Sökning: "Utvecklingsbiologi"

Visar resultat 11 - 15 av 255 avhandlingar innehållade ordet Utvecklingsbiologi.

  1. 11. Chromatin Insulators and CTCF: Architects of Epigenetic States during Development

    Författare :Rituparna Mukhopadhyay; Rolf Ohlsson; Karim Malik; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA methylation; CTCF; Chromatin insulators; Microarray; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : A controlled and efficient coordination of gene expression is the key for normal development of an organism. In mammals, a subset of autosomal genes is expressed monoallelically depending on the sex of the transmitting parent, a phenomenon known as genomic imprinting. LÄS MER

  3. 12. CTCF and Epigenetic Regulation of the H19/Igf2 Locus

    Författare :Vinod Pant; Rolf Ohlsson; Rainer Reinkawitz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; Chromatin; H19; Igf2; CTCF; Insulator; methylation; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : An overall coordination between the expressions of genes is required for the proper development of an individual. Although most genes are expressed from both the constituent alleles of the genome, a small subset of autosomal genes are preferentially expressed from only one of the parental alleles, a phenomenon known as genomic imprinting. LÄS MER

  4. 13. Growth and Behaviour : Epigenetic and Genetic Factors Involved in Hybrid Dysgenesis

    Författare :Wei Shi; Reinald Fundele; Diethard Tautz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Interspecies hybridization; hybrid dysgenesis effect; speciation; genomic imprinting; epigenetics; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : In mammals, the most frequently observed hybrid dysgenesis effects are growth disturbances and male sterility. Profound defects in placental development have been described and our work on hybrids in genus Mus has demonstrated putative hybrid dysgenesis effects that lead to defects in lipid homeostasis and maternal behavior. LÄS MER

  5. 14. The Epigenetics of Gene Transcription and Higher Order Chromatin Conformation

    Författare :Vijay Kumar Tiwari; Rolf Ohlsson; Terumi Kohwi-Shigematsu; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA-protein interactions; Nuclear organization; Transcriptional regulation; Higher order chromatin conformations; Epigenetic reprogramming; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : It is becoming increasingly clear that long-range control of gene expression is mediated through direct physical interactions between genes and regulatory elements, either intra- or interchromosomally. In addition to transcriptional initiation, formation of active chromatin hubs seem to be crucial for increased transcriptional efficiency as well as insulation from neighbouring heterochromatic environment. LÄS MER

  7. 15. Genomic Imprinting in Development and Evolution

    Författare :Joanne Whitehead; Rolf Ohlsson; Andras Paldi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Genetic information is encoded by the linear sequence of the DNA double helix, while epigenetic information is overlayed as the packaging of DNA and associated proteins into the chromatin structure. Variations in chromatin structure play a vital role in establishing and maintaining patterns of gene expression during differentiation and development of higher eukaryotes, and disruption of this epigenetic gene regulation can lead to cancer. LÄS MER