Sökning: "Unmyelinated"

Visar resultat 6 - 10 av 26 avhandlingar innehållade ordet Unmyelinated.

1. 6. Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence

   Författare :Yu Ming; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Aging; dorsal root ganglion; spinal cord; muscle; neurotrophins; GFRalpha; Ret; FGF-2; gp 130; CNTF; LIF; IL-6; receptors; protein; mRNA; glia; axon dystrophy; demyelination.;

   Sammanfattning : A hallmark of senescence is sensorimotor impairment, characterized by gait disturbance, deficits in postural control, and muscle weakness. The object of this thesis work was to elucidate some of the molecular basis underlying these disturbances, mainly referring to the occurrence of characteristic changes in gene-expression pattern, especially, alterations in trophic signaling associated with the phenotypic changes seen in motoneurons as well as primary sensory neurons and target muscles during aging. LÄS MER

3. 7. Neuronal tracers for fine caliber spinal primary afferents and their response to peripheral nerve injury

   Författare :H Fredrik Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Rat; Primary afferents; Dorsal root ganglion; Peripheral nerve injury; Spinal cord; Isolectin GSA I-B4; Soybean agglutinin; Cholera toxin B subunit; Horseradish peroxidase; Immunohistochemistry; Neuronal tracing;

   Sammanfattning : The isolectin B4 from Griffonia simplicifolia I (B4) and soybean agglutinin from the plant Glycine max (SBA), have been shown to bind to rat small-diameter dorsal root ganglion (DRG) neurons, and to fibers and presumed terminals in laminae I-II of the spinal cord dorsal horn. In the present thesis, these lectins and/or their horseradish peroxidase (HRP) conjugates, have been investigated in the rat with regard to their usefulness as selective neuronal markers of and axonally transported tracers for somatic and/or visceral spinal primary afferents with fine caliber, including unmyelinated, axons. LÄS MER

4. 8. Tetrodotoxin-resistant sodium channels in neuropathic pain

   Författare :Jenny Fjell Hjelmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :spinal sensory neurons; nociceptor; IB4; tetrodotoxin; sodium channels; SNS PN3; NaN SNS2; gene regulation; NGF; GDNF; in situ hybridization; immunofluorescence; sodium currents; neuropathic pain models; Taiep;

   Sammanfattning : Injury to the peripheral nervous system can cause neuropathic pain. Abnormal sodium channel activity has been implicated as a source of ectopic firing and changes in nociceptive threshold following nerve injury. LÄS MER

5. 9. Corticosteroids in Lumbar Disc Surgery

   Författare :Anders Lundin; Olle Nilsson; Björn Rydevik; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; lumbar disc heniation; corticosteroids; outcome; thermal quantitative sensory testing; QST; VAS; disability rating index; DRI; microscopic discectomy; Kirurgi; Surgery; Kirurgi;

   Sammanfattning : In a prospective randomised double-blind study eighty patients with MRI verified lumbar disc herniation and corresponding clinical findings underwent microscopic disc removal. The patients were peroperatively given systemic and local corticosteroids or placebo, and followed for 2 years. LÄS MER

7. 10. Structural and functional studies on nerve regeneration in the rat

   Författare :Bo Povlsen; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Peripheral nerves cannot be repaired, but they may be helped to regenerate. The results of surgical treatment of nerve injuries remain disappointing, however. This is a biological rather than a technical challenge. LÄS MER