Sökning: "Umpolung"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Umpolung.

1. 1. New Methodologies in Organic Chemistry: Applications to the Synthesis of α-Amino Acids and Natural Products

   Författare :Sebastian Hirner; Peter Somfai; Varinder Aggarwal; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic synthesis; 2-Vinylaziridines; 3-Pyrrolines; Ringexpansion; Rearrangement; Anisomycin; Total synthesis; α-Amino acids; Arylglycines; Weinreb amides; α-Arylation; Grignard reagents; Umpolung; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis deals with the development and application of new synthetic methodology in organic chemistry. The first part describes the development of a new protocol for the synthesis of 3-pyrrolines by means of a microwave-assisted ring-expansion reaction of 2-vinylaziridines. LÄS MER

3. 2. Multicomponent Catalytic Reactions : Theoretical and Experimental Studies

   Författare :Martin Pauze; Enrique Gomez Bengoa; Belen Martin-Matute; Vincent Gandon; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; C-H Activation; Quaternary Quinolinium; Organocatalyst; Transition Metal Catalyst; Umpolung Strategy; Multi-step Reactions; Mechanistic Investigation; Density Functional Theory; organisk kemi; Organic Chemistry;

   Sammanfattning : In this thesis, Density Functional Theory (DFT) methods have been applied to study the mechanisms of three different multicomponent organic reactions. Also, a new synthetic procedure for the preparation of quinolinium salts is presented, and its mechanism also studied by DFT calculations. LÄS MER

4. 3. Enols and Allylic Alcohols as Building Blocks in Synthetic Organic Chemistry : Experimental and Theoretical Studies

   Författare :Alba Carretero Cerdán; Belén Martín‐Matute; Shu-Li You; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Base catalysis; Ion-pair; Isomerization; MOFs; Hypervalent Iodine III ; DFT; Organic Chemistry; organisk kemi;

   Sammanfattning : The present thesis describes computational and experimental studies used to drive the reactivity of allylic and enol substrates towards new transformations. These synthetic methods give access to a number of organic molecules that may serve as important moieties in synthetic organic chemistry. LÄS MER

5. 4. Selective Transformations of Allylic Compounds and Enol Derivatives : Synthesis of Fluorinated and Nitrogenated Scaffolds

   Författare :Víctor García-Vázquez; Belén Martín‐Matute; Mario Waser; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fluorinated compounds; Base catalysis; Ion-Pair; Isomerization; Pd catalysis; Method development; Hypervalent iodine III ; Organic Chemistry; organisk kemi;

   Sammanfattning : In this thesis, new synthetic methods to give access to molecules having fluorinated scaffolds and other polar functional groups have been developed. The methods give access to highly valuable organic compounds that may serve as building blocks in the synthesis of functionalized drug candidates. LÄS MER

7. 5. Catalytic Methods to Convert Allylic Substrates through Hydride and Proton Shifts : Transition Metal-Catalyzed and Organocatalyzed Approaches

   Författare :Samuel Martinez-Erro; Belén Martín-Matute; Franziska Schoenebeck; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Allylic substrates; Iridium catalysis; Base catalysis; Method development; Isomerization; Hydride shift; Proton shift; Mechanistic studies; organisk kemi; Organic Chemistry;

   Sammanfattning : The present thesis describes the development of new catalytic protocols to transform allylic substrates into a wide variety of versatile carbonyl and vinyl organic compounds. All procedures that are described in this work have in common the existence of one or more hydrogen shifts as key steps in the mechanism of the reactions. LÄS MER