Sökning: "Ulf O. Karlsson"

Hittade 5 avhandlingar innehållade orden Ulf O. Karlsson.

1. 1. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

   Författare :Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
   Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

   Sammanfattning : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. LÄS MER

3. 2. Direct Thrombin Inhibitors in Treatment and Prevention of Venous Thromboembolism: Dose – Concentration – Response Relationships

   Författare :Marie Cullberg; Mats O. Karlsson; Ulf G. Eriksson; Nick H.G. Holford; Uppsala universitet; []
   Nyckelord :Pharmaceutical biosciences; Ximelagatran; pharmacokinetic; pharmacodynamic; activated partial thromboplastin time; utility function; dosing strategy; venous thromboembolism; NONMEM; Farmaceutisk biovetenskap;

   Sammanfattning : For prevention and treatment of thrombotic diseases with an anticoagulant drug it is important that an adequate dose is given to avoid occurrence or recurrence of thrombosis, without increasing the risk of bleeding and other adverse events to unacceptable levels. The aim of this thesis was to develop mathematical models that describe the dose-concentration (pharmacokinetic) and concentration-response (pharmacodynamic) relationships of direct thrombin inhibitors, in order to estimate optimal dosages for treatment and long-term secondary prevention of venous thromboembolism (VTE). LÄS MER

4. 3. Electronic materials : growth and characterisation

   Författare :Michael A. Grishin; Ulf O. Karlsson; Massimo Sancrotti; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electrophysics; Photoemission; Ultra-short laser pulse; Thin film; Laser deposition; InSb; InAs; GaSb; Ferroelectrics; Elektrofysik; Electrophysics; Elektrofysik;

   Sammanfattning : In this thesis the InSb(111), InAs(111) and GaSb(001) surfaces have been studied by means of time- and angle-resolved photoemission spectroscopy based upon the femtosecond laser system. The pump-and-probe technique allows to analyse both electron states in the valence band and normally unpopulated electron states above the valence band, which can be occupied by transiently excited carriers at the optically pumped surface. LÄS MER

5. 4. Studies of Surface and Interface Properties of 4H-SiC/Si02

   Författare :Chariya Virojanadara (Jacobi); Ulf Karlsson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The thesis work is focused on photoemission studies of clean and oxidized 4H-SiC surfaces since 4H-SiC has been considered the most promising for device applications. Oxide layers can be easily grown by standard wet and dry oxidation methods but to obtain good interface properties (i.e. LÄS MER

7. 5. Surface Reactivity and Electronic Structure of Metal Oxides

   Författare :Anneli Önsten; Ulf Karlsson; Anne Borg; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; oxides; surfaces; defects; cuprous oxide; zinc oxide; magnetite; water; OH; sulfur dioxide; photoelectron spectroscopy; scanning tunneling microscopy; Material physics with surface physics; Materialfysik med ytfysik;

   Sammanfattning : The foci of this thesis are the metal oxides Cu2O, ZnO and Fe3O4 and their interaction with water and sulfur dioxide (SO2). The intention is to study SO2-induced atmospheric corrosion on a molecular level. All studies are based on photoelectron spectroscopy (PES) and scanning tunneling microscopy (STM) measurements. LÄS MER