Sökning: "Ulf Gyllensten"

Visar resultat 11 - 15 av 23 avhandlingar innehållade orden Ulf Gyllensten.

  1. 11. Contribution of Immunogenetic Factors in Susceptibility to Cervical Cancer

    Författare :Emma Ivansson; Ulf Gyllensten; Patrik Magnusson; Allan Hildesheim; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical genetics; Medicinsk genetik;

    Sammanfattning : Cervical cancer is the second most common cancer in women worldwide. Persistent infection by an oncogenic type of human papillomavirus (HPV) is a necessary but not sufficient cause and there is also a genetic component. LÄS MER

  3. 12. Genome Variation in Human Populations : Exploring the Effects of Demographic History and the Potential for Mapping of Complex Traits

    Författare :Åsa Johansson; Ulf Gyllensten; Marta Alarcon; Andrew Clark; Uppsala universitet; []
    Nyckelord :Genetics; genetics; evolution; microsatellie; SNP; selection; linkage disequilibrium; haplotype; Genetik;

    Sammanfattning : A major challenge in human genetics is to understand the genetic variation underlying common diseases. In this thesis, I focus on forces creating differences between individuals and genomic regions, methods for characterizing genomic variation, and the association between genomic and phenotypic variation. LÄS MER

  4. 13. Analysis of genetic susceptibility to cervical cancer using candidate gene and GWAS approaches

    Författare :Ivana Juko-Pecirep; Ulf Gyllensten; Holger Luthman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cervical cancer; association study; human papillomavirus; genetics; complex disease; TMC6; TMC8; MHC region; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Cervical cancer is the forth most commonly diagnosed cancer among women worldwide. It is caused by persistent infection with an oncogenic type of Human Papillomavirus (HPV). The HPV is a necessary but not sufficient cause of cervical cancer. LÄS MER

  5. 14. On Transcriptome Sequencing

    Författare :Daniel Klevebring; Joakim Lundeberg; Ulf Gyllensten; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptome; RNA-seq; DNA sequencing; gene expression profiling; non-coding RNA; small RNA; Functional genomics; Funktionsgenomik; Bioinformatics; Bioinformatik; Genetics; Genetik; Molecular biology; Molekylärbiologi; Cell biology; Cellbiologi;

    Sammanfattning : This thesis is about the use of massive DNA sequencing to investigate the transcriptome. During recent decades, several studies have made it clear that the transcriptome comprises a more complex set of biochemical machinery than was previously believed. LÄS MER

  7. 15. Functional Role of Genetic Polymorphisms Associated with Systemic Lupus Erythematosus

    Författare :Sara E Löfgren; Ulf Gyllensten; Jan Hillert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; systemic lupus erythematosus; genetic association; single nucleotide polymorphism; IRF5; CD226; miR-146a; Medical Science; Medicinsk vetenskap; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disorder characterized by a failure in the mechanism of self-tolerance and production of autoantibodies, potentially affecting any organ in the body. The genetic factors behind the disease have been extensively studied in the past years and to date a list of more than 30 loci have been associated with SLE. LÄS MER