Sökning: "Ubiquitin Ligase"

Visar resultat 6 - 10 av 71 avhandlingar innehållade orden Ubiquitin Ligase.

  1. 6. Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites

    Författare :Annika Pfeiffer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result in the loss of integrity of both complementary DNA strands. LÄS MER

  3. 7. SUMO and ubiquitin : the yin and yang of IGF-1R function

    Författare :Bita Sehat; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tumorigenesis is a multistep process involving genetic and epigenetic alterations that drive the progressive transformation of normal human cells into highly malignant derivatives. The insulin-like growth factor 1 receptor (IGF-1R) plays pivotal roles in cancer. LÄS MER

  4. 8. Interplay between the Myc oncoprotein, cyclin-dependent kinases and E3 ubiquitin ligases

    Författare :Hamid Reza Sharifi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mammalian cells grow, divide, and die in a precise and orderly fashion. For cells to grow and maintain their integrity they need to communicate at both intracellular and extracellular level. LÄS MER

  5. 9. Regulation of Hsp70 function by nucleotide-exchange factors

    Författare :Naveen Kumar Chandappa Gowda; Claes Andréasson; Gary Jones; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Heat shock proteins Hsps ; Hsp70; Molecular chaperones; Nucleotide-exchange factors NEFs ; Protein quality control PQC ; Proteostasis; Ubiquitin-proteasome system; Cell Biology; cellbiologi;

    Sammanfattning : Protein folding is the process in which polypeptides in their non-native states attain the unique folds of their native states. Adverse environmental conditions and genetic predisposition challenge the folding process and accelerate the production of proteotoxic misfolded proteins. LÄS MER

  7. 10. From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes

    Författare :Laura K Herzog Croona; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, the DNA is subject to tightly regulated surveillance processes that sense, signal and repair DNA lesions. LÄS MER