Sökning: "U937"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet U937.

  1. 1. Functional studies of Wilms’ tumor gene 1 (WT1) in hematopoiesis and leukemia

    Författare :Helena Svedberg; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; K562; U937; CD34 ; leukemia; WT1; hematopoiesis; Hematologi; extracellulära vätskor;

    Sammanfattning : Wilms’ tumor gene 1 (WT1) is a zinc-finger transcription factor that is involved in the development of urogenital organs and mesothelial tissues. It was initially identified as a tumor suppressor gene, based on the observation that somatic inactivation of the gene predispose for development of the pediatric kidney cancer Wilms’ tumor. LÄS MER

  3. 2. Evolving the Methodology for Detection of Primary DNA Damage : Development, adaptation and assessment of the single cell gel electrophoresis (comet) assay

    Författare :Erik Bivehed; Björn Hellman; Hanna Karlsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Comet assay; DNA damage; DNA strand breaks; Flash-comet; Genotoxicity; In vitro; Single cell gel electrophoresis; Polymerase assisted DNA damage assay PADDA ; TK6 cells; UCDAS; U937 cells; Toxikologi; Toxicology; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Deoxyribonucleic acid (DNA) is one of the most important molecules in nature. It is the fundamental carrier of evolutionary information and constitutes the genetic blueprint of all living organisms. Being the sole source of information, it is vital for the cell to transmit the correct genetic information from generation to generation. LÄS MER

  4. 3. Cellular Effects of Cystatins

    Författare :Samar Hunaiti; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cystatin C; Cystatin D; Galectin-1; Puncta assay; HoloMonitor; Cancer cells; Apoptosis; Cathepsin C;

    Sammanfattning : The exact cellular functions of cystatins are still unknown, and the molecular mechanism leading to their internalization into cells is not yet fully understood. Commonly the cystatins are known to inhibit human lysosomal cysteine proteases (cysteine cathepsins) and it is supposed that this is their primary physiological role. LÄS MER

  5. 4. Molecular dissection of Bruton’s tyrosine kinase signaling in hematopoietic cells using RNAi

    Författare :Juhana E Heinonen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : RNA mediated gene silencing, RNA interference (RNAi), has recently been identified in mammalians. This thesis describes the utilization and development of RNAi based tools for signal transduction research. The effects of Bruton s tyrosine kinase (Btk) down-regulation with RNAi have been studied with gene expression profiling in hematopoietic cells. LÄS MER

  7. 5. Evolution and host-specific adaptations of Legionella pneumophila

    Författare :Anaísa B. Moreno; Lionel Guy; Dan I. Andersson; Fredrik Söderbom; Alexander W. Ensminger; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Evolution; Legionella pneumophila; host-adaptation; experimental evolution; Acanthamoeba castellanii; transfection; Mikrobiologi; Microbiology;

    Sammanfattning : How bacteria evolve pathogenic traits is shaped by their communities and environments. Legionella pneumophila is ubiquitous in aquatic habitats, where it persists by replicating within a broad range of protozoan hosts. Using the same mechanisms, L. LÄS MER