Sökning: "Type 2 metabolism"

Visar resultat 1 - 5 av 390 avhandlingar innehållade orden Type 2 metabolism.

1. 1. The role of galectin-1 in type 2 diabetes. Clinical and experimental studies

   Författare :Emanuel Fryk; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectin-1; type 2 diabetes; human; adipose tissue; metabolism;

   Sammanfattning : Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and mass-spectrometry, we found increased galectin-1 levels in the subcutaneous adipose tissue in a small experimental study of 15 men with and without type 2 diabetes. LÄS MER

3. 2. Systems Biology of Type 2 Diabetes in Skeletal Muscle

   Författare :Leif Väremo; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genome-scale metabolic model; metabolism; skeletal muscle; myocyte; type 2 diabetes; network analysis; gene-set analysis; transcriptomics; gene expression; obesity;

   Sammanfattning : Type 2 diabetes (T2D) is a heterogeneous and complex disease that currently affects more than 350 million people worldwide. A wide range of risk factors influence the pathogenesis of T2D, including genetic and epigenetic components, as well as controllable factors such as diet, obesity, and sedentary lifestyle. LÄS MER

4. 3. Leptin and the Intersection of Cardiovascular Disease, Metabolism, and Adipose Tissue

   Författare :Camilla Vavruch; Fredrik Nyström; Carl Johan Östgren; Johan Ärnlöv; Kristina Boström; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leptin; Type 2 diabetes mellitus; Adipose tissue; Cardiovascular disease; Metabolism; Cardiovascular risk factors;

   Sammanfattning : According to the World Health Organization, cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels, and it is the leading cause of death worldwide. The risk factors for CVD are divided into two major classes: non-modifiable (age, gender, family history) and modifiable (including tobacco use, type 2 diabetes mellitus (T2DM), physical inactivity, unhealthy diet, abdominal obesity, high cholesterol, dyslipidemia, and stress). LÄS MER

5. 4. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases

   Författare :Terrence Heathfield; Enheten för led- och mjukvävnadsforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; Metabolism; Biochemistry; collagen; fibromodulin; cartilage; osteoarthritis; Biokemi;

   Sammanfattning : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. LÄS MER

7. 5. Lipid Metabolism and Insulin Signalling in Adipocytes : enhanced autophagy in type 2 diabetes

   Författare :Anita Öst; Peter Strålfors; Johanna Gustavsson Dahlberg; Anna Krook; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Energy storage in the adipose tissue, to an extent leading to obesity, is associated with local as well assystemic insulin resistance. When insulin-producing beta-cells in the pancreas gradually fail tocompensate, plasma levels of glucose rise and overt type 2 diabetes is diagnosed. LÄS MER