Sökning: "Type 2: drug therapy"

Visar resultat 1 - 5 av 63 avhandlingar innehållade orden Type 2: drug therapy.

  1. 1. Identification of new disease mechanisms and treatments for type 2 diabetes based on genetic variants and gene expression networks

    Författare :Annika Axelsson; Diabetes - öpatofysiologi; []
    Nyckelord :Type 2 diabetes; insulin; ADRA2A; genotype; gene network analysis; SOX5; drug repositioning; sulforaphane; clinical study; typ 2-diabetes; insulin; ADRA2A; genotyp; gennätverksanalys; SOX5; sulforafan; klinisk studie;

    Sammanfattning : Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. LÄS MER

  3. 2. Pharmacoepidemiologic Studies of Diabetes Mellitus - with special reference to - Glucose Control and Prognosis of Type 2 Diabetes

    Författare :Jonny Olsson; Samhällsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; cohort study; longitudinal study; cross-sectional study; mortality; diabetes mellitus; Pharmacoepidemiology; prevalence; type 2 diabetes; diabetes costs; short-term sick-leave; premature retirement; production losses; inpatient care; glycaemic control; fasting blood glucose; oral antihyperglycaemic agents; sulphonylurea; metformin; insulin; combination treatment; drug utilization; prescribed daily doses; safety; effectiveness; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : The efficacy and safety of antihyperglycaemic drugs have been evaluated in one American and one British randomized clinical trial, which have given contradictory results. The positive results of the latter may be more convincing as it included a greater number of patients and as its duration was longer. LÄS MER

  4. 3. Epidemiological and Clinical Aspects of Hormonal Contraception and Menopausal Hormone Therapy in Women

    Författare :Micaela Sundell; Jan Brynhildsen; Anna-Clara Spetz Holm; Mats Fredrikson; Mikael Hoffmann; Ian Milsom; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hormonal contraceptives; Obesity; Menopausal hormone therapy; Hormone replacement therapy; Pulmonary embolism; Premature menopause; Pharmacoepidemiology;

    Sammanfattning : Background: The main indications for therapy with female sex hormones are contraception and menopausal hormone therapy (MHT). The aim of this thesis was to investigate the use of hormonal contraception and MHT in different populations of women in Sweden, 2000–2021. The use of contraception in women with obesity was studied. LÄS MER

  5. 4. Off-label drug use, medication errors and adverse drug events : among Swedish pediatric inpatients

    Författare :Per Nydert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: In pediatrics, treatment with drugs is an important and fully integrated part of everyday medical practice. However, authorized drugs specified to be used in children are often lacking which leads to off-label use, i.e. outside of approved product monographs. LÄS MER

  7. 5. Tumour Survival Signals and Epigenetic Gene Silencing in Multiple Myeloma : Implications for Biology and Therapy

    Författare :Charlotte Fristedt Duvefelt; Helena Jernberg-Wiklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; Polycomb; apoptosis; cIAP2; IAP-inbibitors; proteasome inhibitors; LBH589; PPP; DZNep;

    Sammanfattning : This thesis is focused on multiple myeloma (MM), a haematological malignancy that still remains incurable. The pathogenesis of MM is not fully understood and there is a large intra-tumour and interclonal genetic variation in MM patients. LÄS MER