Sökning: "TxA2"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet TxA2.

  1. 1. Studies on antibodies against phospholipids

    Författare :Leopold Årfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Antiphospholipid syndrome; anticardiolipin antibodies; lupus anticoagulants; platelets; platelet activation; complement activation; endothelial cells; thromboxane; prostacyclin; acetylsalicylic acid.;

    Sammanfattning : The main clinical features of the antiphospholipid syndrome (APLS) are arterial and venous thrombosis, repeated spontaneous abortions and thrombocytopenia. Diagnosed concomitant with an underlying disease the designation is secondary APLS; otherwise primary APLS. LÄS MER

  3. 2. Effects of high glucose on platelet activation

    Författare :Masoud Razmara; Karolinska Institutet; Karolinska Institutet; Karolinska institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus (DM) is associated with increased cardiovascular mortality and morbidity, due to diabetic angiopathy. Hyperglycaemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated the mechanisms underlying hyperglycaemia-induced platelet hyperreactivity and its impact in diabetic patients. LÄS MER

  4. 3. Inhaled Nitric Oxide Therapy : Non-response and Rebound Response

    Författare :Luni Chen; Eddie Weitzberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; nitric oxide inhalation; rebound response; non-response; endothelin-1; COX inhibitor; prostaglandin; ARDS; endotoxin; oleic acid; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård; Clinical Physiology; klinisk fysiologi;

    Sammanfattning : Therapeutic inhaled nitric oxide (INO) has proved beneficial in patients with pulmonary hypertension. However, around 30-40% of the patients are non-responders to this therapy, and a life-threatening rebound response may occur during attempts to withdraw INO. LÄS MER

  5. 4. Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo

    Författare :Cristine Skogastierna; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density lipoproteins, is a principle risk factor, but also elevated triglycerides and low levels of high-density lipoprotein cholesterol. LÄS MER

  7. 5. Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition

    Författare :Masoud Razmara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus (DM) is associated with increased cardiovascular morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated mechanisms underlying hyperglycemia-induced platelet dysfunction, and its impact in DM patients. LÄS MER