Sökning: "Twist Transcription Factor"

Hittade 4 avhandlingar innehållade orden Twist Transcription Factor.

  1. 1. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

    Författare :E-Jean Tan; Aristidis Moustakas; Carl-Henrik Heldin; Geert Berx; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. LÄS MER

  3. 2. Gain-of-function induced defects by PITX2 in eye and limb development

    Författare :Johan K Holmberg; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : My research has been focused on eye and limb development with regard to the transcription factor PITX2. In the first paper we present an Axenfeld-Rieger syndrome PITX2 gain-of-function eye mouse model. Axenfeld-Rieger syndrome is a rare autosomal disorder affecting the development of eyes, teeth and abdomen. LÄS MER

  4. 3. Targeting double-stranded DNA with locked nucleic acid-based (LNA) oligonucleotides (ON) and DNA-binding peptide conjugates

    Författare :Y Vladimir Pabón-Martínez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis we have studied two different types of molecules that bind to the major groove of the DNA: (i) oligonucleotides (ONs) containing locked nucleic acid (LNA) and in combination with intercalating agents (Twisted Intercalating Nucleic Acid, TINA, and Benzoquinoquinoxaline, BQQ) and (ii) peptides mimicking the leucine zipper transcription factor (GCN4 bZIP TF). Both ONs and peptides bind to the DNA double helix aiming to serve as transcription regulators of disease related genes. LÄS MER

  5. 4. The cell cycle regulators p18Ink4c and p19Ink4d : in vivo studies of their roles in tumorigenesis and development

    Författare :Lisa Nilsson; Olle Heby; Martine Roussel; Klas Wiman; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi;

    Sammanfattning : Progression through the G1, S, G2 and M phases of the cell cycle is controlled by cyclin-dependent kinases (Cdks) and cyclins. These proteins form active Cdk:cyclin complexes that phosphorylate specific substrates. LÄS MER