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Visar resultat 21 - 25 av 37 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Nuclear mechanisms in cell death induced by HAMLET (human alpha-lactalbumin made lethal to tumour cells)

    Författare :Caroline Düringer; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mikrobiologi; virology; mykologi; bakteriologi; virologi; mycology; bacteriology; Microbiology; chromatin; histones; apoptosis; alpha-lactalbumin; programmed cell death;

    Sammanfattning : HAMLET (human alpha-lactalbumin made lethal to tumour cells), a protein-lipid complex originally isolated from human milk, induces programmed cell death selectively in tumour cells. It consists of partially unfolded alpha-lactalbumin in complex with oleic acid. LÄS MER

  3. 22. Natural and induced immunity against the tumour-associated antigen, Ep-CAM

    Författare :Szilvia Mosolits; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumour immunology; Ep-CAM; anti-idiotypic antibodies; vaccination;

    Sammanfattning : The tumour-associated antigen (TAA), Ep-CAM is overexpressed on various human carcinomas, including colorectal carcinoma (CRC). TAAs or their immunodominant epitopes that are spontaneously recognised by the immune system might constitute a suitable target for immunotherapy. LÄS MER

  4. 23. The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives

    Författare :Petter Storm; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HAMLET; cancer; cell death; c-Myc; glycolysis; hexokinase; ion channels; p38 MAPK; lipids; colon cancer; beta-catenin;

    Sammanfattning : Despite recent advances in cancer treatment, truly innovative approaches are required to move beyond the modest benefits achieved to date. HAMLET is a human protein-lipid complex originally discovered in breast milk able to kill a wide range of tumour cells while leaving healthy, differentiated cells unaffected. LÄS MER

  5. 24. T Cell recruitment in human Helicobacter pylori associated diseases

    Författare :Karin Enarsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Helicobacter pylori (Hp) infection is associated with pronounced infiltration of granulocytes and lymphocytes into the gastric mucosa, resulting in active chronic gastritis that may develop into duodenal ulcer disease or gastric adenocarcinoma (GC). Infiltrating T cells play a major role in the pathology of these diseases, but the signals involved in recruitment of T cells from blood to H. LÄS MER

  7. 25. Profiling the cancer proteome

    Författare :Sofia Waldemarson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; Biotechnology; Bioteknik; cancerology; oncology; Cytology; iTRAQ; biomarkers; DIGE; two-dimensional gel electrophoresis; Proteomics;

    Sammanfattning : Cancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. LÄS MER