Sökning: "Tumour biology"

Visar resultat 21 - 25 av 139 avhandlingar innehållade orden Tumour biology.

1. 21. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies

   Författare :Andreas Höglund; Jonas Nilsson; Thomas Helleday; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; DNA damage; Decitabine; Chk1; Chk2; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. LÄS MER

3. 22. Microarray Based Gene Expression Analysis in Cancer Research

   Författare :Cecilia Laurell; Joakim Lundberg; Peter Nilsson; Karin Dahlman-Wright; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenocortical tumour; apoptosis; cancer; classification; gene expression; microarray; p53; RNA amplification; Molecular biology; Molekylärbiologi;

   Sammanfattning : Biotechnological inventions during the 20th century have resulted in a wide range of approaches for explorations in the functional genomics field. Microarray technology is one of the recent advances which have provided us with snapshots of which genes are expressed in cells of various tissues and diseases. LÄS MER

4. 23. Studies of Stroma Formation and Regulation in Human Pathological Conditions and in Experimental in vivo Models

   Författare :Alejandro Rodriguez; Christian Sundberg; Kristian Pietras; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; Tumor Stroma; Myofibroblast; Pericyte; Angiogenesis; Inflammation; adenovirus; Tumour biology; Tumörbiologi; Molecular medicine; Molekylär medicin; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : Fibrosis is a sequel of chronic inflammation and is defined as an excessive deposition of collagen that ultimately leads to organ dysfunction. To date there are no effective treatments for fibrosis. The main cell type involved in collagen deposition and organization is the myofibroblast. LÄS MER

5. 24. Biomarker Discovery in Cutaneous Malignant Melanoma : A Study Based on Tissue Microarrays and Immunohistochemistry

   Författare :Margrét Agnarsdóttir; Fredrik Ponten; Peter Naredi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody-based proteomics; automated analysis; biomarker; immunohistochemistry; malignant melanoma; survival; tissue microarray; Tumour biology; Tumörbiologi; Pathology; Patologi; Molecular medicine; Molekylär medicin; Medical Science; Medicinsk vetenskap; Pathology; Patologi;

   Sammanfattning : The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. LÄS MER

7. 25. The CpG island methylator phenotype in colorectal cancer : studies on risk and prognosis

   Författare :Anna Dahlin; Richard Palmqvist; Bethany van Guelpen; Maria Henriksson; Åke Öberg; Xiao-Feng Sun; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; DNA methylation; folate; microsatellite instability MSI ; prognosis; risk factors; t-lymphocytes; the CpG island methylator phenotype CIMP ; Vitamin B12; Pathology; Patologi; Tumour biology; Tumörbiologi; patologi; Pathology;

   Sammanfattning : Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. LÄS MER