Sökning: "Tumor suppressor genes"

Visar resultat 21 - 25 av 195 avhandlingar innehållade orden Tumor suppressor genes.

  1. 21. Molecular alterations in squamous cell carcinomas of the skin : emphasis on genes on chromosome 9q

    Författare :Lena Eklund; Johan Hansson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Skin cancer is the most common type of cancer in the western world. The incidence of melanoma and non-melanoma skin cancer is continuously increasing and, in Sweden, 2300 new cases per year are diagnosed of squamous cell carcinoma (SCC) alone. LÄS MER

  3. 22. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy

    Författare :Mireia Palomar Siles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. LÄS MER

  4. 23. Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53

    Författare :Meiqiongzi Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows evasion of cell death and rapid tumor progression. LÄS MER

  5. 24. The role of hnRNP A1 and hnRNP C1/C2 in the regulation of the stress responsive genes Cyp2a5/2A6 and p53

    Författare :Kyle Christian; Matti Lang; Françoise Raffalli-Mathieu; Kirsi Vähägangas; Uppsala universitet; []
    Nyckelord :Molecular biology; hnRNP; Tumor Suppressor Protein p53; CYP2A5; CYP2A6; Apoptosis; hnRNP C Proteins; hnRNP protein A1; Cancer; Molekylärbiologi;

    Sammanfattning : The family of proteins known as heterogeneous nuclear ribonucleoproteins (hnRNPs) is large and diverse. Often, one and the same hnRNP will perform multiple cellular functions, leading to their description as “multifunctional proteins”. LÄS MER

  7. 25. Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3

    Författare :Hajnalka Kiss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; tumor suppressor gene; large scale sequencing; LIMD1; LZTFL1; FYC01; TMEM7; LRRC2; LUZP3.;

    Sammanfattning : An experimental system, called the elimination test (Et), was developed to identify tumor growth antagonizing genes. Chromosome 3 containing microcell hybrids (MCHs) were passaged through SCID mice and regular deletion of the short arm of chromosome 3 (3p) were found by cytogenetic and molecular methods. LÄS MER