Sökning: "Tumor microenvironment"

Visar resultat 6 - 10 av 195 avhandlingar innehållade orden Tumor microenvironment.

  1. 6. Extratumoral effects of highly aggressive prostate cancer

    Författare :Kerstin Strömvall; Anders Bergh; Sofia Halin Bergström; Göran Landberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; tumor instructed normal tissue; TINT; non-malignant prostate tissue; lymph nodes; lymph node metastasis; pre-metastatic niche; tumor microenvironment; tumor macroenvironment; tumor immunoediting; Dunning rat model of prostate cancer;

    Sammanfattning : Prostate cancer (PC) is the most common cancer in Sweden. Most patients have slow growing tumors that will not cause them any harm within their lifetime, but some have aggressive tumors and will die from their disease. LÄS MER

  3. 7. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Författare :Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER

  4. 8. Immunologic Markers in the Tumor Microenvironment of Classical Hodgkin Lymphoma

    Författare :Alex R. Gholiha; Gunilla Enblad; Rose-Marie Amini; Peter Hollander; Gustaf Hedström; Arjan Diepstra; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor microenvironment; immunohistochemistry; immune checkpoints; Plasma cells; IL-6 cytokine; Proteomics; CD47.;

    Sammanfattning : In classical Hodgkin lymphoma (cHL), cytokine regulation and cellular composition of the tumor microenvironment (TME) is crucial for tumor cell survival. In paper I, we examined the presence of CD138+ plasma cells and IgG4+ plasma cells in diagnostic cHL biopsies with immunohistochemistry (IHC). LÄS MER

  5. 9. Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes

    Författare :Alireza Labani Motlagh; Lucia Mincheva-Nilsson; Ola Winqvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; EOC; HGSC; exosomes; NKG2D; MICA B; ULBP; DNAM-1; PVR; nectin-2; lncRNAs; immune suppression; anti-tumor immunity; NK-cell cytotoxicity; cytokines; Th1; Th2; T regulatory response; inflammation; tumor microenvironment;

    Sammanfattning : Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. LÄS MER

  7. 10. CysLT1 receptor signaling and the tumor microenvironment in colon cancer models

    Författare :Janina Osman; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer CRC ; Cysteinyl leukotriene receptor 1; Tumor microenvironment; Cancer stem-like cells;

    Sammanfattning : .... LÄS MER