Sökning: "Tumor microenvironment"

Visar resultat 11 - 15 av 195 avhandlingar innehållade orden Tumor microenvironment.

  1. 11. Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment

    Författare :Vasiliki Pantazopoulou; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; glioblastoma; tumor microenvironment; reactive astrocytes; hypoxia; CD44; p75NTR;

    Sammanfattning : Glioblastoma is the most aggressive primary brain tumor in adults. Despite treatment, tumors invariably recur, and the recurring tumor is resistant to therapies. New approaches are needed for the successful treatment of glioblastoma patients.Tumors are not simply a compilation of molecularly and phenotypically identical neoplastic cells. LÄS MER

  3. 12. Endothelial activation and inflammation in the tumor microenvironment

    Författare :Hua Huang; Anna Dimberg; William C. Aird; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor angiogenesis; endothelial activation; leukocyte recruitment; VEGF-A; αB-crystallin; ELTD1;

    Sammanfattning : Tumors are composed not only of malignant cells, but also of various types of normal cells, including vascular cells and infiltrating immune cells, which drive tumor development and progression. The tumor vasculature is abnormal and dysfunctional due to sustained tumor angiogenesis driven by high levels of pro-angiogenic factors. LÄS MER

  4. 13. Utilizing Biopolymers in 3D Tumor Modeling and Tumor Diagnosis

    Författare :Negar Abbasi Aval; Torbjörn Pettersson; Aman Russom; Maria Tenje; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3D tumor modeling; Spheroids; Cellulose Nano Fibrils; Layer by Layer; Extracellular matrix; Circulating Tumor Capturing; Pancreatic ductal adenocarcinoma PDAC ; 3D-tumörmodellering; Sfärer; Cellulosa; Lager-på-lager; Extracellulärmatris; Infångning av cirkulerande tumörceller; Mänskliga Duktala Adenocarcinom-Hepatocyter; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : Cancer represents a significant global public health challenge and ranks as the second mostcommon cause of death in the United States. The onset of cancer entails an initial phasewhere cells lose their polarity and disconnect from the normal basement membrane, allowingthem to form distinct three-dimensional (3D) configurations that interact with adjacent cellsand the surrounding microenvironment. LÄS MER

  5. 14. CD40L Gene Therapy for Solid Tumors

    Författare :Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

    Sammanfattning : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. LÄS MER

  7. 15. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Författare :Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Sammanfattning : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. LÄS MER