Sökning: "Tumor Suppressor Genes"
Visar resultat 1 - 5 av 195 avhandlingar innehållade orden Tumor Suppressor Genes.
1. Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C
Sammanfattning : Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further understand tumorigenesis and aid in the discovery of a new treatment leading toward cure of cancer. LÄS MER
2. Identification and characterization of candidate genes for neuroblastoma development
Sammanfattning : Neuroblastoma (NB) is the most common tumor during infancy. It arises from undifferentiated cells in the sympathetic nervous system and is characterized by both clinical and genetic heterogeneity. One of the features of NBs with unfavorable outcome is loss on distal chromosome 1p. LÄS MER
3. The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment in these young children can also be severe. LÄS MER
4. On the role of the retinoblastoma tumor suppressor gene in hematopoietic differentiation
Sammanfattning : The aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. LÄS MER
5. On the Role of the Tumor Suppressor p53 in Leukemic Cell Differentiation
Sammanfattning : Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. LÄS MER