Sökning: "Tumor Necrosis Factor alpha"

Visar resultat 11 - 15 av 89 avhandlingar innehållade orden Tumor Necrosis Factor alpha.

1. 11. Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease

   Författare :Erik Ulfhammer; Göteborgs universitet; []
   Nyckelord :tissue-type plasminogen activator; endothelium; fibrinolysis; hypertension; shear stress; strain; antihypertensive agents; inflammation; TNF-alpha; NF-kappaB; MAPK;

   Sammanfattning : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local protective response to prevent thrombus extension. LÄS MER

3. 12. Effects of Biomechanical Stress on Gene Regulation in Vascular Cells

   Författare :Maria Carlström; Göteborgs universitet; []
   Nyckelord :shear stress; intraluminal pressure; endothelium; gene expression; DNA microarray; real-time RT-PCR; reference genes; smooth muscle cells; P2 receptors; TNF-alpha; urokinase-type plasminogen activator;

   Sammanfattning : The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to regulate a number of fundamental vascular functions, such as vascular tone and remodeling processes. LÄS MER

4. 13. Role of adhesion molecules and chemokines in TNF-alpha-induced leukocyte recruitment

   Författare :Xiao Wei Zhang; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intravital microscopy; microcirculation; inflammation; adhesion; leukocyte; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : Migration of leukocytes from the circulating blood into the extravascular tissue is a key component in inflammatory reactions. Leukocyte extravasation (rolling-activation-adhesion-transmigration) is strictly coordinated by adhesion molecules and chemokines expressed on cell surfaces and in tissues. LÄS MER

5. 14. Factors Regulating Neurogenesis in Intact and Pathological Brain: Role of TNF-alpha

   Författare :Robert Iosif; Lunds universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : During the last decade it has been clearly demonstrated that the adult brain contains neural stem cells (NSCs) localized mainly in two regions: the subgranular zone in the dentate gyrus and the subventricular zone (SVZ) lining the lateral ventricles. In the intact brain, these NSCs give rise to new dentate granule cells and olfactory bulb neurons, respectively. LÄS MER

7. 15. Effect of Drugs on Rabbit Retina

   Författare :Anna Cardiakidis Myers; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug toxicity; electroretinography; histopathology; intravitreal injection; rifabutin; anti-VEGF; triamcinolone; benzyl alcohol; anti-TNF-alpha; adalimumab;

   Sammanfattning : The adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. LÄS MER