Sökning: "Triosephosphate Isomerase"

Hittade 3 avhandlingar innehållade orden Triosephosphate Isomerase.

  1. 1. Computational Studies of Enzymatic Enolization Reactions and Inhibitor Binding to a Malarial Protease

    Författare :Isabella Feierberg; Modesto Orozco; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Theoretical chemistry; enzyme mechanism; enolate; molecular dynamics; empirical valence bond; glyoxalase I; ketosteroid isomerase; triosephosphate isomerase; malaria; aspartic protease; plasmepsin; linear interaction energy; drug design; Teoretisk kemi; Theoretical chemistry; Teoretisk kemi; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Enolate formation by proton abstraction from an sp3-hybridized carbon atom situated next to a carbonyl or carboxylate group is an abundant process in nature. Since the corresponding nonenzymatic process in water is slow and unfavorable due to high intrinsic free energy barriers and high substrate pKa s, enzymes catalyzing such reaction steps must overcome both kinetic and thermodynamic obstacles. LÄS MER

  3. 2. Computational Modeling of the Structure, Function and Dynamics of Biomolecular Systems

    Författare :Yashraj Kulkarni; Shina Kamerlin; Markus Meuwly; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular Dynamics; Empirical Valence Bond; Enzyme Catalysis; Amyloid Beta; Aβ; Triosephosphate Isomerase; TIM; Computational Biochemistry; Computational Enzymology; Biokemi; Biochemistry;

    Sammanfattning : Proteins are a structurally diverse and functionally versatile class of biomolecules. They perform a variety of life-sustaining biological processes with utmost efficiency. A profound understanding of protein function requires knowledge of its structure. LÄS MER

  4. 3. Computational protein crystallography : How to get the most out of your data

    Författare :Justin Bergmann; Beräkningskemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hirshfeld atom refinement HAR ; ; quantum refinement; protein crystallography; X-ray crystallography; neutron crystallography; nitrogenase; acetylcholin esterase; triose isomerase;

    Sammanfattning : It is important to obtain accurate three dimensional structures of molecules and proteins to understand and predict their function and behaviour. X-ray crystallography is the major technique to determine three dimensional structures of proteins. LÄS MER