Sökning: "Treatment effect heterogeneity"

Visar resultat 6 - 10 av 103 avhandlingar innehållade orden Treatment effect heterogeneity.

  1. 6. DNA methylation profiling of CNS tumors; implications for clinical diagnostics

    Författare :Sandra Ferreyra Vega; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Central nervous system tumors; DNA methylation; clinical diagnostics; diffuse gliomas; meningiomas; heterogeneity;

    Sammanfattning : Diffuse gliomas and meningiomas are the most common primary tumors of the central nervous system (CNS) in adults and these tumors cause significant morbidity and mortality worldwide. Deregulation of the epigenetic mechanisms, e.g. LÄS MER

  3. 7. Deregulated epigenetics and cancer stem cells in brain tumours

    Författare :Anna Wenger; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer stem cell; glioblastoma; paediatric; methylation; heterogeneity; CRISPR;

    Sammanfattning : Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, but these epigenetic mechanisms are reversible and can potentially be corrected by treatment. LÄS MER

  4. 8. Essays on Educational Choice and Intergenerational Mobility

    Författare :Martin Nybom; Anders Björklund; Markus Jäntti; Mikael Lindahl; Stockholms universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; educational choice; treatment effect heterogeneity; returns to college; noncognitive ability; intergenerational income mobility; life-cycle bias; time trends; cross-country differences; Economics; nationalekonomi;

    Sammanfattning : This thesis consists of four self-contained essays. The first essay concerns educational choice and the returns to college in Sweden. I apply a recently introduced econometric framework that allows for self selection and treatment effect heterogeneity. LÄS MER

  5. 9. Urban Snowmelt Processes: Modelling and Observation

    Författare :Annette Semadeni Davies; Avdelningen för Teknisk vattenresurslära; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; geographical and geological engineering; Hydrogeology; energy; runoff; snow properties; heterogeneity; hydrological modelling; Urbanisation; snowmelt; Hydrogeologi; teknisk geologi; teknisk geografi; Geophysics; physical oceanography; meteorology; Geofysik; fysisk oceanografi; meteorologi;

    Sammanfattning : In northern Scandinavia and other cold regions, urban drainage systems are often unable to cope with the high volumes of melt water which can be sustained for several weeks. High waste water treatment plant inflows, combined system overflows and low water quality are a few problems associated with snowmelt. LÄS MER

  7. 10. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

    Författare :Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

    Sammanfattning : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. LÄS MER