Sökning: "Transthyretin Amyloidosis"
Visar resultat 26 - 30 av 30 avhandlingar innehållade orden Transthyretin Amyloidosis.
26. Synthesis and application of β-configured [18/19F]FDGs : Novel prosthetic CuAAC click chemistry fluoroglycosylation tools for amyloid PET imaging and cancer theranostics
Sammanfattning : Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. LÄS MER
27. Amyloid aggregates: detection and interaction
Sammanfattning : The research on protein aggregation and amyloid formation is motivated by the fact that amyloid formation in tissue is harmful and associated with several debilitating diseases including Alzheimer’s disease (AD) and systemic amyloidosis such as transthyretin (ATTR) amyloidosis. Nevertheless, their beneficial roles in Nature have recently been identified, and artificial self-assembling of amyloid structure for various applications are emerging. LÄS MER
28. Studies of amyloid toxicity in Drosophila models and effects of the BRICHOS domain
Sammanfattning : Amyloid diseases involve specific protein misfolding events and formation of fibrillar deposits. The symptoms of these diseases are broad and dependent on site of accumulation, with different amyloid proteins depositing in specific tissues or systematically. LÄS MER
29. Cardiac arrhythmias and heart rate variability in familial amyloidotic polyneuropathy : A clinical study before and after liver transplantation
Sammanfattning : Familial amyloidotic polyneuropathy (FAP), found in the northernmost counties in Sweden, is a rare, lethal and inherited amyloidosis. The disease is caused by mutated transthyretin (TTR). The mutation is characterized by an exchange of valine for methionine at position 30 (ATTRVal30Met). LÄS MER
30. Apolipoprotein A-1 derived amyloid in the atherosclerotic intima of the human aorta
Sammanfattning : Amyloid is insoluble fibrillar protein deposited in the extracellular space. The resulting heterogeneous group of disorders, amyloidosis, can be sporadic or hereditary, and the amyloid is systemically distributed or localized in single organs. LÄS MER