Sökning: "Transthyretin Amyloidosis"

Visar resultat 21 - 25 av 30 avhandlingar innehållade orden Transthyretin Amyloidosis.

  1. 21. Structural studies of FocB and Transthyretin

    Författare :Ulrika Wikström Hultdin; Elisabeth Sauer-Eriksson; Inger Andersson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : The molecular structure of a protein decides its function, its way to interact with other molecules. Using X-ray crystallography methods, a 3-dimensional, atomic model of a macromolecule can be determined. LÄS MER

  3. 22. Understanding the dual nature of lysozyme: part villain – part hero : A Drosophila melanogaster model of lysozyme amyloidosis

    Författare :Linda Helmfors; Ann-Christin Brorsson; Bengt-Harald (Nalle) Jonsson; R. Luke Wiseman; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Amyloid proteins are a distinct class of proteins that can misfold into β-sheet rich structures that later mature to form the characteristic species known as amyloid fibrils, and accumulate in tissues in the human body. The misfolding event is often caused by mutations (or outer factors such as changes in pH) that destabilize the native protein structure. LÄS MER

  4. 23. Accumulation and Cellular Clearance of IAPP and Proteotoxicity of ATTR in Drosophila Models

    Författare :Xiaohong Gu; Gunilla Westermark; Anders Olofsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; ATTR; ATTR amyloidosis; crystalline structure; aggrephagy; Drosophila melanogaster; Gal4-UAS; electron tomography; DAMS; SOHA; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Proteins’ functions are dependent on their three-dimensional (3D) structure. Under certain circumstances, proteins misfold and form aggregates, sometimes leading to amyloidosis. Islet amyloid polypeptide (IAPP) builds up amyloid in the pancreatic islet of patients with type 2 diabetes (T2D). LÄS MER

  5. 24. Patient stratification and treatment effects in diseases with disturbed cardiac function

    Författare :Gabriel Granåsen; Urban Wiklund; Frida Sandberg; Umeå universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biostatistics; Heart rate variability; Cardiac amyloidosis; hypertrophic cardiomyopathy; cluster analysis; Echocardiography; Long QT syndrome; Pediatric; Statins; Coronary artery calcium; Computer tomography; Machine learning; Predictive modeling;

    Sammanfattning : Background: Cardiovascular disease characteristics are often measured using a combination of different measurement modalities. By combining information from these modalities using statistical modelling we can gain additional knowledge about these diseases. LÄS MER

  7. 25. Prefibrillar oligomeric Transthyretin mutants - amyloid conformation, toxicity and association with Serum amyloid P component

    Författare :Karin Andersson; Erik Lundgren; Anne Clark; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Amyloidoses represent a heterogeneous group of diseases characterized by abnormal protein metabolism leading to extracellular deposition of fibrillar, proteinaceous amyloid in various tissues and organs of the body. To date more than 20 different proteins have been linked to diseases with amyloid depositions, of which Alzheimer’s disease and the prion-associated diseases are the most well known. LÄS MER