Sökning: "Transcriptome"

Visar resultat 11 - 15 av 326 avhandlingar innehållade ordet Transcriptome.

1. 11. Systems Biology in Saccharomyces cerevisiae. Statistical data analysis and mathematical methods

   Författare :Roberto Olivares Hernandez; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transcriptome; Systems Biology; Proteome; Integrative Analysis; Fluxome;

   Sammanfattning : Over the last decade, Systems Biology has emerged as a new paradigm in the study of cellular systems which are characterized from a global perspective; in contrast to the traditional cellular biology, which was focused on specific components of the cell. To this end, a key milestone for the achievement of a global view of biology is the generation and interpretation of different datasets derived from omics technologies; such as Transcriptome and Proteome. LÄS MER

3. 12. Systems Biology of Yeast Lipid Metabolism

   Författare :Pramote Chumnanpuen; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transcriptome; Integrated analysis; Lipidome.; Inositol-choline; Opi1; Yeast lipid metabolism; high throughput techniques; Ino4; TORC1; Snf1; Ino2;

   Sammanfattning : Lipid metabolism plays an important role in the development of many different life-style related diseases, such as type 2 diabetes and atherosclerosis, and understanding the molecular mechanisms behind regulation of lipid biosynthesis and degradation may lead to development of new therapies. In this project we undertook a global study of lipid metabolism in the eukaryotic model organism Saccharomyces cerevisiae. LÄS MER

4. 13. Transcription regulation and growth phase transition in hyperthermoacidophilic archaea

   Författare :Kun Wang; Ann-Christin Lindås; Finn Werner; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Archaea; Sulfolobus; Transcription regulation; Lrp; TetR; BarR; ChIP-seq; RNA-seq; Transcriptome; growth phase transition; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Organisms from the domain Archaea are ubiquitously represented on our planet and encompass diverse fascinating organisms. The genus Sulfolobus belonging to the phylum Crenarchaeota including hyperthermoacidophilic strains that grow optimally at 65-85°C and pH 2-3. LÄS MER

5. 14. Physiology of Saccharomyces cerevisiae Producing Recombinant Insulin in Continuous Culture

   Författare :Ali Kazemi Seresht; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; unfolded protein response; Keywords: heterologous protein production; prolonged chemostat; transcriptome; insulin analogue precursor; metabolic adaptation; URA3d; plasmid copy number; promoter truncation; high cell density cultivation; TPI1;

   Sammanfattning : The yeast Saccharomyces cerevisiae has widely been used as a host for the production of heterologous proteins. High-level production of heterologous proteins is likely to impose a metabolic burden on the host cell and can thus affect various aspects of cellular physiology. LÄS MER

7. 15. Regulation of RNA Editing : The impact of inosine on the neuronal transcriptome

   Författare :Mikaela Behm; Marie Öhman; André Gerber; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; miRNA; Neuron; Brain development; Synapse; Molecular Biology; molekylärbiologi;

   Sammanfattning : The transcriptome of the mammalian brain is extensively modified by adenosine to inosine (A-to-I) nucleotide conversion by two adenosine deaminases (ADAR1 and ADAR2). As adenosine and inosine have different base pairing properties, A-to-I RNA editing shapes the functional output of both coding and non-coding RNAs (ncRNAs) in the brain. LÄS MER