Sökning: "Transcription"

Visar resultat 6 - 10 av 1971 avhandlingar innehållade ordet Transcription.

1. 6. Regulation of Human Mitochondrial DNA Replication and Transcription

   Författare :Majda Mehmedovic; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mtDNA; replication; transcription; TFAM;

   Sammanfattning : Mitochondria are organelles in eukaryotic cells, which through oxidative phosphorylation (OXPHOS) produce most of the ATP used to drive cellular processes. The organelle contains its own genetic material, mitochondrial DNA (mtDNA), which encodes 13 key components of the OXPHOS machinery. LÄS MER

3. 7. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors

   Författare :Marina Tshuikina Wiklander; Fredrik Öberg; Kenneth Nilsson; Ugo Testa; Uppsala universitet; []
   Nyckelord :Medical sciences; IRF family; ICSBP IRF8; epigenetics; ATRA; TNFα; histone modifications; methylation; transcription; MEDICIN OCH VÅRD;

   Sammanfattning : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. LÄS MER

4. 8. Exploring and predicting DNA template dependent variation in transcription

   Författare :Harriet Mellenius; Måns Ehrenberg; Johan Elf; Dan Andersson; Otto Berg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transcription; accuracy; kinetic proofreading; selection; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : Reliable transmission of information from DNA to proteins is a pre-requisite for all life, where substitution errors in the polypeptide chain may arise from transcription, aminoacylation of tRNAs or translation. The fidelity control mechanisms in transcription have nevertheless received little attention, based on the assumption that the transcriptional error is masked by the translational error. LÄS MER

5. 9. Structure-function relationships of the human Runx1 transcription factor

   Författare :Magnus Wolf-Watz; KTH; []
   Nyckelord :Runx1; Runt domain; CBFâ; transcription; leukemia; protein structure; protein dynamics;

   Sammanfattning : Runx transcription factors contain a DNA-binding andtransactivating α-subunit and a β-subunit (CBFβ)that serves to increase the DNA binding affinity of theα-subunit. The DNA binding domain of Runx proteins isnamed the Runt homology domain (RD) after its strong sequencehomology to theDrosophilaprotein Runt. LÄS MER

7. 10. Viral Strategies to Regulate Transcription and Pre-mRNA Splicing

   Författare :Shaoan Fan; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Adenovirus E1B-55kDa; E4-ORF4; E4-ORF6 proteins; L1 mRNA; Polyoma virus small T antigen; regulation; transcription; splicing; PP2A; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

   Sammanfattning : A typical DNA virus encodes for a few key regulatory proteins that modify the host cell biosynthetic machinery to achieve a selective viral gene statement. One such example is illustrated by the adenovirus E4-ORF4 protein, which form an enzymatically active complex with the serine and threonine-specific protein phosphatase 2A (PP2A). LÄS MER