Sökning: "Transactivation function"
Visar resultat 21 - 25 av 50 avhandlingar innehållade orden Transactivation function.
21. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription
Sammanfattning : Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine involved in the production and function of hematopoietic cells, and GM-CSF plays in particular a major role in responses to infection and physiological and pathological inflammatory processes. GM-CSF is produced in many cell types, and increases in the intracellular Ca2+ concentration are, like in many other systems, of major importance in the intracellular signaling that determines GM-CSF expression after receptor stimulation of the cells. LÄS MER
22. Functional analysis of ligand recognition by the glucocorticoid receptor
Sammanfattning : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. LÄS MER
23. Notch signaling : from receptor cleavage to chromatin remodeling
Sammanfattning : One of the principal signaling mechanisms that control development of multicellular organisms is the Notch signaling pathway. The transmembrane Notch receptor, presented at the cell surface, interacts with ligand on neighbouring cells. LÄS MER
24. Targeting of the Myc pathway as a novel approach for cancer therapy
Sammanfattning : As transcription factors, Myc-family proteins function upstream of signaling pathways and regulate cell proliferation, differentiation, angiogenesis, apoptosis and transformation. Precisely regulated Myc expression is critical for cellular physiology, while perturbations of Myc expression have detrimental consequences to the organism. LÄS MER
25. p73 : regulator of differentiation and apoptotic cell death
Sammanfattning : Neoplasia is characterized by cells' loss of self-control due to deregulated apoptotic and cell proliferation pathways. Anticancer treatments aim to induce either cell cycle arrest or apoptosis, and these effects are in most part mediated by proteins, like p53 and p73, which are involved in and able to mediate both processes. LÄS MER