Sökning: "Transactivation function"
Visar resultat 16 - 20 av 50 avhandlingar innehållade orden Transactivation function.
16. p53 reactivation by the small molecule RITA : molecular mechanisms
Sammanfattning : Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer cells. Therefore, reactivation of p53 appears to be a promising strategy for anti-cancer therapy. LÄS MER
17. Studies on two transcription regulatory proteins : cellular c-Jun and adenovirus E1A
Sammanfattning : Adenoviruses cause lytic infections in a range of mammalian cells, but can in certain cases also transform the host cell. The first adenovirus gene to be expressed upon infection is E1A. The E1A gene encodes two major proteins of 243 and 289 amino acids, respectively, both of which serve as key regulators during virus infection. LÄS MER
18. Epidermal Reactions to Injury with Implications for Innate Immunity
Sammanfattning : Abstract The epidermis is one of our primary interfaces towards the external milieu. Following injury, the physical barrier function of the skin is destroyed and the epidermis is left vulnerable to microbial invasion. LÄS MER
19. Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators
Sammanfattning : Nuclear receptors (NRs) are ligand-dependent transcription factors. The DNA-bound receptors either positively or negatively regulate transcription of target genes. The receptors regulate transcription through interaction with transcription coregulators and recruitment of components of the basal transcription machinery. LÄS MER
20. Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms
Sammanfattning : The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional independent domains, the N-terminal domain containing a major transactivation region, the central DNA binding domain (DBD) and the C-terminal domain that binds the hormone/ligand. LÄS MER